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Theories and ideas for understanding human life-span development, particularly for behavioral and psychological development, emphasize postnatal development and postnatal exposures. That interest is intensely subdivided according to theories, disciplines, and research traditions. For example, much of the field of developmental psychology focuses on the normative changes in social, emotional, cognitive, and physical health in the first two decades of life. The implicit notion is that these early years compose a particularly important period in the life span for understanding development qua development, and that there might also be salutary lessons for study of these years for understanding how best to promote healthy development. Somewhat less attention focuses on development in the later years, although that is fast changing because there is now wide appreciation for the urgent need to understand individual differences in (older) aging, and why differences in behavioral and somatic health from individual to individual may become accentuated in the last decades of life. By comparison, the prenatal period is not much emphasized in theories of life-span human development—that is, aside from a generally undifferentiated tacit respect for the prenatal period and recognition of a few specific prenatal priorities, such as how prenatal maternal smoking causes preterm birth or that folate is needed to prevent neural tube defects such as spina bifida. This entry highlights recent advances elevating the importance of the prenatal period for life-course somatic, behavioral, and psychological development, and it positions the study of prenatal exposures as offering a compelling—sometimes complementary and sometimes competing—account for individual differences in life-span human development.

Defining and Mapping Prenatal Development

One of the first tasks in discussing the prenatal period is to provide the embryological background. Classic embryology texts and models have been developed over many decades; these are well represented in the 23 Carnegie stages, which track fetal age, embryonic length, biological changes, and physical appearance. The Carnegie stages describe cellular changes of the blastocyst to implantation to—much later—the recognition of elbows, knees, and toes. Other developmental lineages also need to be described in embryological terms, such as the development of the placenta, the formation of the maternal–fetal–placenta unit, and the governing of exchange of information such as the passage of and genesis of hormones and the formation of the fetal blood-brain barrier. Embryology and organogenesis are fundamentally concerned with the following question: When in development does a particular organ or function or capacity emerge, and why? These are truly fundamental questions that enlist advances in genetics and evolutionary biology.

Egg, Embryo, and Fetus

There are other complementary models for defining and mapping early (i.e., prenatal) development. Gestation is also organized as the successive periods of the egg, the embryo, and the fetus. The first period, from fertilization to approximately 1 week postfertilization, describes the time during gestation preceding implantation; in other words, the period of the formation of the zygote until the blastocyst is positioned in the uterus. The period of the embryo, or the second stage, covers implantation to approximately the 8th week of gestation. It is during this period that the shape of the conceptus is more readily recognizable, with rudimentary physical features of a head and limbs; there is also a beating heart. During the period of the fetus, which extends from the 9th week of gestation until birth, there is considerable and rapid growth, cell differentiation, and organ system development. The Carnegie stages and the period of the egg, the embryo, and the fetus are biologically based distinctions that are no doubt much less well-known than the simpler system of referring to the first, second, and third trimesters of pregnancy.

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