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Mental and physical disorders resulting from the use of drugs and alcohol are highly prevalent in the United States, with males affected 2 to 3 times more frequently than females. These disorders have debilitating effects, as they are associated with increased mortality rates, homelessness, child maltreatment, homicide, suicide, and other problem behaviors that extensively tax the health care system. The American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) includes a general category for these disorders called substance related disorders, which is further broken down into two general categories: substance use disorders and substance-induced disorders. Substance use disorders include the diagnoses of substance abuse and substance dependence, while substance-induced disorders include substance intoxication, substance withdrawal, and eight additional substance-induced mental disorders. These substance-induced mental disorders include substance-induced delirium, substance-induced persisting dementia, substance-induced persisting amnestic disorder, substance-induced psychotic disorder, substance-induced mood disorder, substance-induced anxiety disorder, substance-induced sexual dysfunction, and substance-induced sleep disorder.

In addition to specific disorders, the DSM-IV-TR divides substances into the following categories: alcohol; cannabis; cocaine; opioids; amphetamines; hallucinogens; caffeine; inhalants; nicotine; phencyclidine; sedatives, anxiolytics, or hypnotics; and other. The specific diagnosis of a substance-induced disorder is based on both the disorder itself and the substance thought to be involved. For example, a diagnosis of intoxication will always be associated with a substance, such as cocaine intoxication or cannabis intoxication. Whereas all categories of substances listed in the DSM-IV-TR have at least one associated substance-induced disorder, each substance-induced disorder may not apply to all types of substances. For example, cannabis can cause intoxication but not persisting dementia or persisting amnestic disorder. The "other" category can be used to diagnose substance-induced disorders occurring as a side effect of prescription medication, for example, sexual dysfunction resulting from antidepres-sant therapies, or those related to toxin exposure.

Assessment of Substance-Induced Disorders

The diagnosis of substance-induced disorders often involves obtaining an extensive psychosocial, and sometimes medical, history by a qualified mental health and medical professional. Psychosocial factors relevant to the disorders may be obtained by a variety of professionals, such as psychologists, psychiatrists, physicians, licensed or certified addiction counselors, or licensed clinical social workers, although the specific qualifications required to make diagnoses may vary by state. For some disorders, such as persisting dementia or persisting amnestic disorder, more specialized training is required to make the diagnosis because it not only is based on the psychosocial interview but may also require specialized physical and neurological examinations (e.g., brain imaging procedures), neuropsychological testing to document deficits in memory and other cognitive abilities, and assessment of functional outcomes. Thus, for some of the substance-induced disorders, the diagnosis is made after extensive evaluation by an interdisciplinary team of professionals, each of whom is specialized to evaluate a specific aspect of the disorder in question. It can often be difficult to assess individuals with substance-induced disorders because there may be strong incentives for them to underreport or deny substance use. It is also the case that because some substances can cause deficits in cognitive abilities such as memory, individuals with long histories ofuse may simply be unable to accurately remember the details of prior use. This is particularly true for substance-induced dementia or amnestic disorder, where memory deficits are required in order to make these diagnoses. Even when sufficient symptoms are present to make a diagnosis, it is often difficult to clearly establish a link between the symptoms and the substance use. For example, in the case of an individual with a history of heavy methampheta-mine use and psychotic episodes, it is not always clear whether the methamphetamine use preceded the psychotic episode or, alternatively, if the methamphetamine was used in an attempt to cope with the preexisting psychotic symptoms. In these instances, history of substance use onset and offset in relation to symptom onset and offset is crucial in determining whether the disorder is substance induced or not. This temporal relationship is especially difficult to determine when mental symptoms continue after intoxication and withdrawal, and clinical judgment is needed to determine whether a substance-induced persisting disorder should be diagnosed or whether a primary mental disorder should be diagnosed.

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