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Certainly one, among many things, at which humans consistently excel is the willingness and desire to alter our consciousness and augment our sensory experiences. The vehicle for humans from prehistoric time to current day is the use of drugs to quickly accomplish this goal (although there are a host of nondrug practices to equally alter consciousness, such as meditation). The large majority of humanity does not suffer from drug addiction; yet, members of every human culture (from Aboriginal to Indian, Chinese, Egyptian, South American, Aleuts, Chukchi, and Eskimo) use psychoactive drugs on a daily basis for a variety of reasons (i.e., pain relief, religious, vision seeking, consciousness expansion, entertainment, as a food source, healing disease, and even seeking immortality).

Historically, the vast majority of drugs used by humans were hallucinogens, and few were central nervous system stimulants or depressants. A mere 300 years ago, plants and fungi were the major sources of psychoactive chemicals, as humans had not yet become clever enough to reproduce complex synthesis routes that plants accomplish with only water, earth, and sunlight. There are over 800,000 species of plants living today; a small fraction of these species (about 4,000) are the best producers of psychoactive substances on the planet, and they were most convenient for human discovery and use.

Why Plants and Fungi Produce Psychoactive Substances

One theory about the purpose underlying the variety of psychoactive chemicals synthesized by plants is believed to be as a chemical defense against organisms that would consume them. Eating a plant or fungus containing psychoactives would disrupt the central nervous system of the animal via stimulant (organism becomes hyperactive, or anorectic and ceases eating the plant) or depressant (organism becomes sleepy and eating ceases). If additional plant substance continued to be consumed, the dose could rise to lethal levels in the case of stimulant and depressant plant substances. Plants and fungi producing hallucinogens (the main effect is to disrupt sensory systems) and eaten by mammals would most likely result in an aver si ve event for the mammal. Again, the organism would discontinue eating.

According to Ronald K. Siegal, practically all animals consume plants and fungi that contain psychoactive substances. Humans could have watched animals eat plants with psychoactive properties and imitated them to develop drug use patterns in neolithic ages. Elephants, koalas, goats, cows, cats, reindeer, rabbits, mice, and birds, respectively, eat fermented fruit (alcohol), eucalyptus leaves, caffeine, locoweed, catnip, mushrooms, belladonna in wild lettuce, and hempseed. An interesting observation is that animals do not seem to prefer the effects of hallucinogens (as demonstrated by drug self-administration research studies). Only humans are known to regularly consume hallucinogens voluntarily and for entertainment purposes.

Drugs of Abuse: Ancient Use History

The study of drug use in humans before the common era (bc) overlaps several areas of study and can include ethnobotony, archeopharmacology, ethno-pharmacology, and the history of drug use with regard to tracing prehistoric, neolithic medicinal and religious plant use in humans. Note that the "factual" dating of evidence in excess of 300 years prior to the common era is considered imprecise and, in many instances, are simply good guesses based on some empirical evidence (i.e., radiocarbon dating, uncovering burial remains, chemical analyses of residue for pottery). For instance, among the oldest reports of evidence in the family Hominidae is archeological evidence of H. neanderthalensis burial sites in Iraq from 50,000 years ago. Examination of plant remains reveals the presence of the natural stimulant herbal ephedra. This evidence seems to support the conclusion that Neanderthals used psychoactive drugs. However, the oldest drugs used by humans, that today are considered drugs of abuse, include depressants, stimulants, and hallucinogens.

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