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SITUATED IN THE northern portion of the Midwestern United States, Wisconsin is widely known as the Dairy State in recognition of its prodigious production of cheese and other dairy products. It is also the site of numerous important scientific, industrial, and cultural contributions throughout its development into a modern and multi—faceted state. Wisconsin is also renowned within the stem cell field as a hub for new research and innovation, centered primarily at the University of Wisconsin, Madison.

Wisconsin was incorporated as the 30th state of the United States of America on May 29, 1848. Wisconsin's capital was eventually established in Madison, although its largest city is Milwaukee. In its early history, Wisconsin was populated primarily by immigrants from New York State, who brought the large—scale dairy farming methods that helped shape the agriculture of Wisconsin. Throughout the second half of the nineteenth century, Wisconsin became an increasingly diverse state, incorporating successive waves of immigrants from Europe, particularly from Germany and the Scandinavian nations. Because of the heavy influence of German culture and heritage in Wisconsin, the state is sometimes dubbed the most German—American state in the Union. This is reflected in many of the cultural traditions of the state, such as Oktoberfest. Wisconsin also contains large populations of people descended from Norwegian and Scandinavian roots, as well as many Asian ethnic groups, including the Hmong. Following the Vietnam War, several cities in Wisconsin were selected as resettlement sites for Hmong refugees displaced by the conflict.

The state of Wisconsin is recognized for its high—quality cheeses and dairy production. The state is also proud of its National Football League championship team, the Green Bay Packers; the Milwaukee Brewers, a Major League Baseball team; and the Milwaukee Bucks of the National Basketball Association.

Involvement in Stem Cell Research

Researchers based in Wisconsin conducted much of the pioneering research in the stem cell field. Dr. James Thomson at the University of Wisconsin, Madison was the first to isolate and culture primate embryonic stem cells in 1995, following this discovery with the successful isolation and culture of human embryonic stem cells in 1998. University of Wisconsin researchers also announced in 2001 that they had successfully induced embryonic stem cells to differentiate into primitive blood cells, and eventually other hema—topoietic cells. Many other research milestones in the stem cell field have also been achieved by scientists based in Wisconsin.

Stem cell research continues to expand and flourish in Wisconsin, and researchers are increasingly focusing on new applications for stem cells. Ongoing research efforts focus on regenerative medicine and on application to specific conditions such as cardiovascular disease, cancer, and neurodegenerative diseases.

Research Infrastructure

A number of important Wisconsin institutions have developed into a supporting infrastructure for advancing stem cell research efforts. One of the chief components of this infrastructure is the state—funded and state—supported University of Wisconsin system, which has been instrumental in many of the key discoveries and advances in stem cell biology. Another key component of Wisconsin's stem cell infrastructure is WiCell, a supporting agency of the University of Wisconsin. WiCell is a provider and distributor of the five unique human embryonic stem cell lines developed at the University of Wisconsin, Madison, providing cells to universities and accredited researchers across the country. WiCell also works to develop research protocols and training programs to advance stem cell research nationally and internationally. WiCell is also designated by the federal government as the site of the National Stem Cell Bank, which holds the 21 human embryonic stem cell lines available for use in federally funded research.

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