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THE REEVE—IRVINE RESEARCH Center (RIRC) is a medical institute located at the University of California, Irvine (UCI), and has a mission to

find new treatments for spinal cord injury through the collaborative research and educational efforts of prominent scientists and clinicians both at the University of California, Irvine, and around the world.

The center is named after the actor Christopher Reeve (1952–2004), who suffered a horse—riding accident that left him paralyzed from the neck down and that indirectly led to his early death from cardiac arrest. He had been a very active person, taking not just his equestrian eventing very seriously but also being a pilot and a sailor, among other sports.

For the remainder of his life, Reeve was a proponent of stem cell research and other forms of spinal cord injury research, which he hoped would create treatments able to help him and other victims of similar injuries. He used his charisma and presence to raise the profile of the injury and its victims, and his memory represents a continuing inspiration to people working at the center.

It was Joan Irvine Smith, a philanthropist, who led the campaign to establish a research center in the name of the actor. Smith is also a noted supporter of equestrian events and provided grants to UCI totaling some US$1 million, with UCI charged with raising an additional US$2 million for the operation of the center. This occurred in 1996 (Reeve suffered his accident in 1995), and the invitation was accepted by both the university and the actor. By 1999, important personnel were in place and work began, with tangible results flowing from the research beginning in 2000. The RIRC has, in the years since, gone from strength to strength.

It was through Smith's previous efforts that UCI was founded as an institution, as she provided 1,000 acres of land, which is now the university's home. Although philanthropy is not, of course, limited to the United States, the country does have a tradition of those who have been materially successful giving back to society that is not replicated in many other countries and that, as in this case, represents a causative function that can stimulate the creation and nurturing of collaborative relationships.

Research

Research at the RIRC is led by four principal investigators (Pis) and 23 associate Pis, who work in laboratories with rodent models (rats and mice) and cell culture systems with a view to identifying potential treatments for spinal injuries and developing existing concepts. The Pis are working in six specific areas: limiting the secondary degeneration occurring after spinal cord injury, enhancing regeneration of damaged nerve cells, human embryonic stem cells, improving motor recovery, autonomie function and pain, and promoting collaboration and cooperation between the RIRC and sister facilities. In terms of stem cell activities, RIRC staff members are involved with the overall UCI effort to develop stem cell research within California and for the benefit of its people. Leading RIRC members Os Steward and Susan Bryant are affiliated with the Independent Citizens Oversight Committee, which has been charged with supervising the California Institute for Regenerative Medicine. Both Steward and Bryant have received positions through appointment by Governor Arnold Schwarzenegger. Using funds disbursed as a result of Proposition 71, the California Stem Cell and Research Initiative, which was passed by referendum of the state's electorate in 2004, together with UCI and private—sector support, an advanced new facility is planned that will house a Stem Cell Research Facility, which will be aimed at using research into human embryonic stem cells as a means of combating neurological disorders. It is hoped that stem cells may be used to replace destroyed nerve cells, to support axon regeneration, or to enhance axon signaling by replacing myelin—forming cells. A number of technical issues remain to be resolved in each of these cases, but progress is being made. RIRC personnel are working with private—sector companies such as Geron Corporation and Stem—Cells, Inc. to convert existing stem cell lines into specific cells with the ability to ameliorate the effects of spinal cord injury.

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