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COLUMBIA UNIVERSITY IS located in New York City. Its roots date back to 1754, when the King of England established the school by royal charter; it was originally known as King's College. Columbia is New York's oldest university and opened the first medical school—the College of Physicians and Surgeons—Granting an M.D. degree in the United States in 1770. When the medical school formed an alliance with Presbyterian Hospital in 1922, it became the first academic medical center in the United States. Columbia offers undergraduate, graduate, and professional programs in a variety of academic disciplines with research opportunities.

The Columbia University Health Sciences campus combines medical care, education, and scientific research (both fundamental research with the ultimate goal of translation into clinical applications and clinical trials). Columbia has long been a leader in stem cell research, experiencing such successes as the first successful transfer of genes from one cell to another, the discovery that embryos and teratomas are made up of rapidly dividing stem cells, making the determination that stem cells have controls at certain points to stop them from dividing outside the uterus, and coating mouse embryonic epithelial cells and inducing them to become motor neurons in cell culture.

Columbia University Medical Center provides patient clinical services, is home to Columbia's medical school, and performs scientific research (both basic research and clinical trials). Stem cell researchers are working on the heart, eye, blood, skin, and immune system. The center's past successes include the discovery that antide—pressants stimulate stem cells to form new brain cells; that embryonic stem cells can be turned into light—sensing neurons; that hair follicle epithelial cells can be used as a source of adult stem cells to regenerate skin; that neural and musculoskel—etal stem cells can be differentiated into motor neurons; that activated stem and immune cells may be useful for leukemia, lymphoma, and solid tumors; and of gene and cell therapy to help pace the heart adult stem cells.

Research Centers and Programs

Audubon Biotechnology and Research Park was developed by the university, the state, and the city of New York in an area adjacent to Columbia University Medical Center. The park houses the Mary Woodard Lasker Biomédical Research building, which opened in October 1995 and is home to the Audubon Business Technology Center; the Russ Berrie Medical Science Pavilion, with specialties in diabetes, genetics, and pediatrics; and the Irving Cancer Research Center, which opened in May 2005. The Audubon Business and Technology Center is an incubator for business start—ups for private research and development in biotechnology with laboratories and regulatory and commerce assistance.

The Naomi Berrie Diabetes Center was established in 1997 and moved into the Russ Berrie Medical Science Pavilion in 1998. The center focuses on combining patient- and family-centered care and education with diabetes research. Researchers are working to create insulin—producing islet cells from stem cells because cell therapies using islet cells transplant are in short supply, and cells and stem cells that are differentiated into islet cells may be a new source.

The Herbert Irving Comprehensive Cancer Center builds on Columbia's long history for cancer research. The center provides patient care and conducts basic and clinical research, including research using stem cells. The center's eight research programs are organized into basic research, disease—specific research, and population—based research. Program activities focus on different aspects of cancer, from its molecular and cellular mechanisms through its unique behavior in different tissues to statistical aspects of its occurrence and treatment in large populations. Researchers are working with cord blood stem cells and cancer therapies to expand a rich source of stem and immune cell transplants for childhood leukemia and solid tumors. Another research project includes the genetic mechanisms that control cell division and gene expression in cancer cells and studies how cancer disrupts DNA repair mechanisms and encourages instability.

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