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Science journalists and other communicators of scientific information often write about—or otherwise respond to—a variety of ethical controversies that arise in research, such as claims about falsified data or the mistreatment of subjects in research. Frequently, when the topic of research ethics is raised, a discussion of “human subjects research” follows. However, research ethics encompasses a broader domain that includes issues beyond those involving the participation of human beings in research or the performance of unethical behavior. Research ethics includes values, regulations, guidelines, and norms that structure how research should be conducted. Further, although the perception tends to be that the focus of research ethics is about forms of misconduct, it is not merely about wrongdoing. Research ethics also addresses the more “positive” facets of research, including how to be more productive, how to create a more collegial environment, and what is needed to uphold the public's trust.

The terms research ethics and responsible conduct of research are often used interchangeably, but they do not always mean the same thing. In some contexts, for example, the former term refers to the more theoretical, philosophical dimensions of research, which may include asking whether ethical theory is useful in resolving a particular research problem. On the other hand, the focus of the latter term tends to be on research compliance, which involves how researchers, administrators, and others should adhere to laws, regulations, and institutional guidelines governing research. Yet when scholars use the term research ethics, frequently they intend to address both philosophical and compliance-related matters.

Among the main types of resources that might assist researchers in the effort to learn about ethically appropriate research practice are ethics codes from professional organizations, institutional guidelines, journal policies, and government regulations and laws. Research ethics discussions also take place in scholarly publications as well as within the pages of other publications that reach scientific communities and the public.

Important Historical Events

Although not an exhaustive list, the following discussion highlights key research ethics cases and events over the last several decades. The growth and interest in the subject matter of research ethics largely originates out of World War II. This is due in part to the role that researchers had in the development of the atomic bomb and other types of weapons. Yet conversations about research ethics more commonly occur in response to the actions of the Nazis. Briefly stated, Nazi researchers performed a variety of cruel, painful, and often fatal experiments on human beings. Their behaviors eventually led to the creation of the Nuremberg Code, which is a set of guidelines that structures human subjects research practices. The paramount ethical value contained within the Nuremberg Code is that voluntary consent must be obtained from human participants before research begins.

Regulations and guidelines for research involving human beings were crafted largely in response to a U.S. Public Health Service syphilis study. The study took place from 1932 to 1972 and was primarily located at the Tuskegee Institute in Alabama. The study's ethical failings include that individuals who suffered from syphilis, approximately 399 African American males, were not informed of this fact and did not receive medical treatment for their disease. Although no proven treatment for syphilis was available when the study began, penicillin was discovered to be a cure in the mid-1940s, and it was not offered to the individuals in the study.

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