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Sugar and Fat Substitutes
Sugar and fat substitutes are used in foods to mimic the taste and organoleptic properties of sugar and fat, yet provide fewer calories and/or lipid. The development of sugar and fat substitutes has enabled the creation of a wide array of dietetic foods, but the efficacy of these food products in weight-loss programs remains unproven. Research indicates that sugar and fat substitutes, when used to reduce overall calorie intake, produce weight loss in feeding studies. However, in public use, there is limited evidence whether these products actually aid consumers' weight-control efforts. Sugar and fat substitutes are widely accepted by the public and are used by millions of people every day in popular foods, but some consumers question the safety of these artificial ingredients and choose to avoid them.
As with other novel food ingredients, sugar and fat substitutes must be preceded by extensive safety testing prior to approval for use in the food supply, and the U.S. Food and Drug Administration (FDA) maintains that they are safe. There is currently no consensus on whether sugar and fat substitutes should be recommended by nutrition and healthcare professionals as dietary modifications to prevent or treat obesity, and whether to consume sugar and fat-modified food products remains an individual's decision.
Sugar substitutes are accepted by the public but some consumers question the safety of artificial ingredients and choose to avoid them.

Sugar and fat substitutes exist in the modern food supply in a variety of forms. The number of available FDA-approved fat and sugar substitutes continues to grow in number, each possessing unique attributes for food and beverage application. These ingredients have enabled the development of highly palatable food, beverage, and confectionary products with reduced or eliminated fat, sugar, and total calories.
While research shows that use of sugar- and fat-modified foods results in decreased energy intake during short-term blinded studies, the widespread use of these compounds in food has been insufficient to slow the climbing obesity rate on an epidemiological scale. One proposed theory maintains that with time, dissociation of perceived sweet taste with energy intake may interfere with appetite regulation. Psychological and behavioral issues also influence the success of sugar and fat substitutes in producing weight loss. Clearly, sugar and fat substitutes can only elicit weight reduction if their consumption leads to a cumulative energy deficit. Use of diet foods as an excuse to eat unlimited quantities is a common problem for unsuccessful dieters. However, the ability to consume highly palatable foods in a less calorically dense form can favorably affect dieter adherence to reduced-calorie regimens, improve quality of life, and avoid weight regain.
Sugar Substitutes
Sugar substitutes, also known artificial sweeteners, impart a sweet taste to foods but either are not metabolized by the body (nonnutritive sweeteners) or are used in such small amounts as to provide negligible calories. The FDA currently has approved five artificial sweeteners as food additives: saccharin, aspartame, acesulfame-K, sucralose, and neotame. Because these products are intensely sweet, only small amounts are needed to replace the sucrose in foods. Thus, even caloric sugar substitutes contribute insignificant energy to the food or beverage. Commonly, recipes using artificial sweeteners must also include starches or other ingredients to account for bulking, moisture-retaining, or browning properties of sugar, which the substitutes lack. In addition to reducing the calorie content of foods, sugar substitutes offer additional benefits that appeal to some consumers. Diabetics may benefit from improved glycemic control when replacing digestible sugars with noncaloric sweeteners, and unlike sugar, artificial sweeteners do not promote tooth decay.
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- Biological or Genetic Contributors to Obesity
- Adipocytes
- Adiponectin
- Adrenergic Receptors
- Agouti and Agouti Related Protein
- Animal Models of Obesity
- Animal QTLs (Quantitative Trait Locus)
- Bardet-Biedl Syndromes
- Cannabinoid Receptor
- CD36 and FAT (Fatty Acid Transporters)
- Cholecystokinin (CCK)
- Cortisol
- Cushing Syndrome
- Cytokines
- Db/Db Mouse
- Dopamine Receptor
- Down's Syndrome
- Epistatic Effects of Genes on Obesity
- Estrogen-Related Receptor
- Familial Lipodystrophies
- Fatty Acid Transport Proteins
- G-Protein Coupled Receptors
- Genetic Taste Factors
- Ghrelin
- Glucagon Receptor
- Glucocorticoids
- Glucokinase
- Growth Hormone
- HDL Receptors
- Histamine Receptor
- Hormone Sensitive Lipase
- Human QTLs
- Hypothyroidism
- Insulin and Insulin Resistance
- Insulin-Like Growth Factors
- Interleukins
- Intrauterine Growth Restriction
- LDL Receptors
- Leptin
- Leptin Receptors
- Lipoprotein Lipase
- Low Birth Weight
- Melanocortins
- Mendelian Disorders Related to Obesity
- Metabolic Rate
- Monogenic Effects that Result in Obesity
- Neuropeptides
- NPY (Neuropeptide Y)
- Ob/Ob Mouse
- Obesity and the Immune System
- Obesity Gene Map
- Opioid Receptor
- Perilipins
- POMC (Proopiomelanocortin)
- PPAR (Peroxisome Proliferator-Activated Receptors)
- Prader-Willi Syndrome
- Protein Kinase
- Set or Settling Point
- Steroids
- Thrifty Gene Hypothesis
- Thrifty Gene Hypothesis and Obesity
- Thyroid Hormone
- TNF (Tumor Nucrosis Factors)
- Transgenics and Knockouts for Obesity-Related Genes
- Tubby Candidate Gene
- Twin Studies and Genetics of Obesity
- Uncoupling Proteins
- Viral Causes of Obesity
- Children and Obesity
- Advertising
- Atherosclerosis in Children
- Bariatric Surgery in Children
- Behavioral Treatment of Child Obesity
- Beverage Choices in Children and Obesity
- Breastfeeding
- Changing Children's Food Habits
- Childhood Obesity as a Risk Factor for Adult Overweight
- Childhood Obesity Treatment Centers
- Children and Diets
- Ethnic Disparities in the Prevalence of Childhood Obesity
- Family Behavioral Interventions
- Family Therapy in the Treatment of Overweight Children
- Flavor Programming and Childhood Food Preferences
- Food Intake Assessments in Children
- Formation and Development of Food Preferences
- Genetic Taste Factors
- Hypertension in Children
- Implications of Restriction of Foods on Child Feeding Habits
- Medical Interventions for Children
- Metabolic Disorders and Childhood Obesity
- Morbid Obesity in Children
- National Weight Loss Efforts for Children
- Overweight Children and School Performance
- Overweight Children and the Media
- Peer Influences on Obesity in Children
- Pharmacological Treatment of Childhood Obesity
- Physical Activity in Children
- Prevalence of Childhood Obesity in Developing Countries
- Prevalence of Childhood Obesity in the United States
- Prevalence of Childhood Obesity Worldwide
- Prevention
- School-Based Interventions to Prevent Obesity
- Self-Esteem and Children's Weight
- Stigmas against Overweight Children
- Type 2 Diabetes
- Dietary Interventions to Treat Obesity
- Atkins Diet
- Calcium and Dairy Products
- Caloric Restriction
- Carbohydrate “Addictions”
- Chromium Picolinate
- Diet Myths
- Dietary Restraint
- Exercise
- Fast Foods
- Fiber and Obesity
- Fruits and Vegetables
- High-Carbohydrate Diets
- High-Protein Diets
- Jenny Craig
- L.A. Weight Loss
- Liquid Diets
- Low-Calorie Diets
- Low-Fat Diets
- Macrodiets
- Medifast
- Non-Diet Approaches
- Nutrisystem
- Nutrition Fads
- Optifast
- Physical Activity and Obesity
- Portion Control
- Slim-Fast
- South Beach Diet
- Supplements and Obesity
- Vegetarianism
- Very Low-Calorie Diets
- Volumetrics
- Water and Obesity
- Weight Watchers
- Zone, The
- Disordered Eating and Obesity
- Anorexia Nervosa
- Antidepressants
- Appetite Signals
- Binge Eating
- Body Dysmorphic Disorder
- Body Image
- Bulimia Nervosa
- Childhood Onset Eating Disorders
- Cognitive-Behavioral Therapy
- Depression
- Dieting: Good or Bad?
- Disinhibited Eating
- DSM-IV
- Eating Disorders and Athletes
- Eating Disorders and Gender
- Eating Disorders and Obesity
- Eating Disorders in School Children
- EDNOS
- Families of Eating Disorder Patients
- Feminist Perspective and Body Image Disorders
- Genetic Influences on Eating Disorders
- Hunger
- Neurotransmitters
- Night Eating Syndrome
- Physiological Aspects of Anorexia
- Physiological Aspects of Bulimia
- Prevalence of Disordered Eating
- Sexual Abuse and Eating Disorders
- Treatment Centers for Eating Disorders
- Weight Cycling and Yo-Yo Dieting
- Environmental Contributors to Obesity
- Accessibility of Foods
- Advertising of Foods to Children
- Children's Television Programming
- Economics of Food
- Energy Density
- Fast Foods
- Food Advertising
- Food Labeling
- Governmental Subsidizing of Energy Dense Foods
- Inaccessibility of Exercise
- Increased Reliance on Automobiles
- Increasing Portion Sizes
- Palatability
- Parental and Home Environments
- Safe Play Opportunities for Children
- School Lunch Programs
- Schools and Obesity
- Sodas and Soft Drinks
- Sugar and Fat Substitutes
- Supersizing
- Television
- Toxic Environment
- Health Implications of Obesity
- Appetite Control
- Asthma
- Atherosclerosis
- Back Pain
- Blood Lipids
- Body Image
- Breast Cancer
- Colon Cancer
- Congestive Heart Failure
- Depression
- Elevated Cholesterol
- Fatty Liver
- Fertility
- Fitness
- Gallbladder Disease
- Gastroesophageal Reflux (GERD)
- Gastrointestinal Disorders
- Gestational Diabetes
- Gout
- High-Density Lipoproteins
- Hormones
- Hypertension
- Impotence
- Kidney Failure
- Kidney Stones
- Low-Density Lipoproteins
- Menstrual Problems
- Mortality and Obesity
- Osteoarthritis
- Osteoporosis
- Ovarian Cancer
- Ovarian Cysts
- Overall Diet Quality
- Polycystic Ovary Disease
- Respiratory Problems
- Sexual Health
- Sleep Apnea
- Stroke
- Type 2 Diabetes
- Urinary Incontinence in Severe Obesity in Women
- Uterine Cancers
- Medical Treatments for Obesity
- American Medical Association
- American Obesity Association
- Amphetamines
- Caffeine
- Cost of Medical Obesity Treatments
- Dexatrim
- Dieting: Good or Bad?
- Ephedra
- Fenfluramine
- Future of Medical Treatments for Obesity
- Gastric Bypass
- Gastroplasty
- Health Coverage of Gastric Surgeries
- International Obesity Task Force
- Laparoscopy
- Liquid Diets
- Low-Calorie Diets
- Medical Interventions for Children
- Medications that Affect Nutrient Partitioning
- Multidisciplinary Bariatric Programs
- Noradrenergic Drugs
- North American Association for the Study of Obesity
- Orlistat (Xenical)
- Physician-Assisted Weight Loss
- Qualifications for Gastric Surgery
- Roux-en-y Gastric Bypass
- Serotonergic Medications
- Sibutramine (Meridia)
- Thyroid Medications
- Vertical Banded Gastroplasty
- Very Low-Calorie Diets
- New Research Frontiers on Obesity
- Acomplia
- Bioelectrical Impedance Analysis
- Bod Pod and Pea Pod
- CART Peptides
- Combined Approaches to Treatment
- Computerized Tomography
- DEXA (Dual Energy X-ray Absorptiometry)
- Dilution Techniques
- Doubly Labeled Water
- Drug Targets that Decrease Food Intake/Appetite
- Drugs that Block Fat Cell Formation
- Energy Expenditure Technologies
- Food Technology
- Frontiers in Maintenance and Prevention
- Functional Foods
- Functional Magnetic Resonance Imaging
- Genetic Mapping of Obesity-Related Genes
- Genomics
- Histamines
- Hormone Disorders
- Hydrodensitrometry
- Indirect Calorimetry
- Intestinal Microflora Concentrations
- Leptin Supplements
- Magnetic Resonance Imaging Scans for Viewing Body Composition
- Metformin
- Microarray Analysis
- New Candidate Obesity Genes
- New Drug Targets that Prevent Fat Absorption
- New Drug Targets to Improve Insulin Sensitivity
- New Drug Targets to Increase Metabolic Rate
- Non-Diet Approaches
- Obesity and Viruses
- Quantitative Trait Locus Mapping
- Rimonabant
- SNP Technologies
- Three-D Image Reconstruction
- Translational Research
- Whole-Body Potassium Counting
- Obesity and Ethnicity/Race
- African Americans
- Asian Americans
- Body Fat Distribution in African Americans
- Body Fat Distribution in Asian Americans
- Body Fat Distribution in Hispanic Americans
- Cardiovascular Disease in African Americans
- Cardiovascular Disease in Asian Americans
- Cardiovascular Disease in Hispanic Americans
- Caucasians
- Dominican Americans
- Ethnic Variations in Body Fat Storage
- Ethnic Variations in Obesity-Related Health Risks
- Genetics
- Health Disparities—NIH Strategic Plan
- Hispanic Americans
- Hypertension in African Americans
- Hypertension in Asian Americans
- Hypertension in Hispanic Americans
- Mexican Americans
- Native Americans
- Obesity and Socioeconomic Status
- Pima Indians
- Puerto Rican Americans
- Sisters Together
- Thrifty Gene Hypothesis
- U.S. Office of Minority Health
- Western Diets
- Obesity and the Brain or Obesity and Behavior
- Antidepressants
- Appetite Control
- Autonomic Nervous System
- Bombesin
- Cannabinoid System
- Central Nervous System
- Cholecystokinin
- Conditioned Food Preferences
- Corticotropin-Releasing Hormone
- Dopamine
- Drugs and Food
- Fat Taste
- Flavor: Taste and Smell
- Folic Acid and Neural Tube Defects
- Food “Addictions”
- Food Reward
- Gustatory System
- Habituation
- Hypothalamus
- Inherited Taste Preferences
- Insulin
- Liking vs. Wanting
- Medications that Increase Body Weight
- Mood and Food
- Neuropeptide-Y
- Neurotransmitters
- Norepinephrine
- Nutrient Reward
- Olfactory System
- Opioids
- Oxytocin and Food Intake
- Peripheral Nervous Sytem
- Pituitary Gland
- Satietin
- Sensory-Specific Satiety
- Sweet Taste
- Sympathetic Nervous System
- Taste Aversion Learning
- Taste Reactivity
- Thyroid Gland
- Tryptophan
- Obesity as a Public Health Crisis
- Access to Nutritious Foods
- American Academy of Pediatrics
- American College of Sports Medicine
- American Diabetes Association
- American Dietetic Association
- American Heart Association
- American Medical Association
- American Obesity Association
- American Society for Bariatric Surgery
- Built Environments
- Center for Maternal and Child Health
- Center for Nutrition Policy and Promotion
- Center for Science in the Public Interest
- Centers for Disease Control and Prevention
- Child Obesity Programs
- Community Level Initiatives to Prevent Obesity
- Community Programs to Prevent Obesity
- Council on Size and Weight Discrimination
- Economics of Obesity
- Expanded Food and Nutrition Program
- Federal Initiatives to Prevent Obesity
- Food and Drug Administration
- Food Guide Pyramid
- Food Labeling
- Food Marketing to Children
- Food Stamp Nutrition Education Program
- Government Agencies
- Head Start
- Healthy Eating Index
- Healthy People 2010
- National Association to Advance Fat Acceptance
- National Cancer Institute
- National Center for Health Statistics
- National Eating Disorders Association
- National Heart, Lung, and Blood Institute
- National Institutes of Health
- NIDDK
- North American Association for the Study of Obesity
- Obesity in Schools
- Office of Dietary Supplements
- Office of Minority Health
- Policy to Prevent Obesity
- President's Council on Physical Fitness and Sports
- Safety of Urban Environments
- School Initiatives to Prevent Obesity
- Shape-Up America!
- Social Marketing and Obesity
- State and Local Initiatives to Prevent Obesity
- Taxation of Unhealthy Foods
- Toxic Environment
- U.S. Department of Agriculture
- U.S. Department of Health and Social Services
- Weight Control Information Network
- Psychological Influences and Outcomes of Obesity
- Addictive Behaviors
- Anorexia Nervosa
- Anxiety
- Binge Eating
- Bulimia Nervosa
- Cognitive-Behavioral Therapy
- Compulsive Overeating
- Depression
- Disordered Eating
- Eating Disorders in School Children
- External Controls
- Loneliness
- Night Eating Syndrome
- Obsessive Compulsive Disorder
- Psychiatric Medicine and Obesity
- Self-Esteem and Obesity
- Stress
- Suicidality
- Well-Being
- Societal Influences and Outcomes of Obesity
- Alcohol
- Appearance
- Body Image
- Breastfeeding vs. Formula Feeding
- Built Environments
- Calcium Intake and Dairy Products
- Carbohydrate and Protein Intake
- Computers and the Media
- Eating Out in the United States
- Fat Acceptance
- Fat Intake
- Flavor Learning
- Food Advertising and Obesity
- Food Guide Pyramid
- Food Intake Patterns
- Food Labeling
- Food Preferences
- Governmental Policy and Obesity
- Income Level and Obesity
- Nutrition Education
- Obesity and Academic Performance
- Obesity and Drug Use
- Obesity and Sports
- Obesity and the Media
- Obesity in Schools
- Personal Relationships and Obesity
- Physical Activity Patterns in the Obese
- Smoking
- Soda and Soft Drink Intake
- Stereotypes and Obesity
- Supersizing
- Variety of Foods and Obesity
- Virtual Environments
- Weight Discrimination
- Western Diet
- Women and Dieting
- Women and Obesity
- Assessment of Obesity and Health Risks
- Bariatric Surgery in Women
- Body Image
- Breast Cancer
- Breastfeeding
- Colon Cancer
- Coronary Heart Disease in Women
- Early Onset Menarche and Obesity in Women
- Economic Disparities among Obesity in Women
- Endometrial and Uterine Cancers
- Estrogen Levels
- Ethnic Disparities among Obesity in Women
- Exercise and Physical Activity among Obese Women
- Fat Acceptance
- Fertility
- Food Preferences
- Gestational Diabetes
- Implications of Gestational Development
- Maternal Influences on Child Feeding
- Menopause and Obesity
- Morbid Obesity in Women
- Obese Women and Social Stigmatization
- Polycystic Ovary Disease
- Pregnancy Prevalence of Obesity in U.S. Women
- Self-Esteem in Obese Women
- Support Groups for Obese Women
- Waist-to-Hip Ratio
- Women and Diabetes
- Women and Dieting
- Worldwide Prevelance of Obesity
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