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Medifast
Medifast is low-calorie weight-loss and weight-maintenance program which relies on a combination of prepackaged Medifast meals and conventional food. Medifast is also the name of the publicly traded company (listed on the New York Stock Exchange) which conducts operations primarily through two wholly owned subsidiaries. Medifast products are produced by Jason Pharmaceuticals, a company founded by William Vitale in 1980, in a production facility in Owings Mill, Maryland, and are marketed by Jason Pharmaceuticals and Take Shape for Life. The latter, founded in 2002, is a network of health advisers supervised by physicians which market Medifast products as part of a wide-ranging “healthy lifestyle” program.
The Medifast Web site emphasizes the use of Medifast products within a healthy lifestyle including exercise, and the maintenance of weight loss through permanent behavioral changes. There is no charge for joining the Medifast program, but following the program requires purchasing a substantial number of Medifast packaged meals. Like the Atkins Diet, the Medifast diet is low in calories and carbohydrates and is intended to put the body into a state of ketosis which is believed to aid in burning fat. During the dieting phase of the Medifast program, an individual will consume 800–1,000 calories per day. Medifast encourages medical supervision of the Medifast diet, although this is not a requirement as the products may be purchased directly through the Medifast Web site. In addition, dieters have the option of enrolling in a Medifast Weight Control Center. These are franchise operations which currently (2007) exist in Texas and Florida and offer medical supervision and counseling for individuals following the Medifast diet.
In the case of some selective serotonin reuptake inhibitors, short-term weight loss is often followed by small or inconsistent weight gain, but the exact mechanism of antidepressant-induced weight gain has not been elucidated.

The basic Medifast diet program is called the “5 & 1 Plan” because it is based on the daily consumption of five prepackaged Medifast meals plus one “lean and green” meal of conventional food. Following this plan, a person eats a small meal every two to three hours, a plan which is intended to keep them from becoming hungry and thus encouraging adherence to the diet. Medifast meals must be purchased from the company and are available in over 50 varieties which are interchangeable; they include shakes, bars, oatmeal, and scrambled eggs. Supplemental snacks such as soup and chips are also available, and there are meals designed specifically for diabetics, and separate meal packages for men and women. Costs for Medifast meals vary, but in May 2007, the discounted cost from the company Web site for four weeks worth of meals was $275. The “lean and green” meal consumed daily consists of conventional food chosen and prepared by the dieter, and is made up of a lean protein such as chicken, fish, or egg whites, and a salad or low-carbohydrate green vegetable.
The Medifast program is divided into three segments: the actual dieting period, the transition period, and the maintenance period. Common to all phases is an educational component focused on making dieters conscious of their food consumption and dietary requirements; in the second and third phases, they must adopt an individualized diet which will allow them to maintain a constant weight. After dieters achieve their target weight, the transition period begins. During this period, dieters begin to eat more normal foods and fewer Medifast meals, gradually increasing their caloric intake, and includes in their diet higher-carbohydrate fruits and vegetables which were avoided during the initial period. During the transition period, dieters continue to eat five or six small meals per day, made up of a combination of conventional food and Medifast meals: the assumption is that dieters are now accustomed to that schedule and has also been trained to choose small portions of food similar to that provided by the packaged meals. The company Web site recommends eight weeks in the transition period for people who lost less than 50 pounds, 12 weeks for those who lost 50–100 pounds, and 16 weeks for those who lost over 100 pounds. During the maintenance period, dieters consume approximately the same number of calories as they burn; frequent consumption of portion-controlled meals remains a cornerstone of this phase (which could last the rest of the person's life) although the use of Medifast meals is optional.
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- Biological or Genetic Contributors to Obesity
- Adipocytes
- Adiponectin
- Adrenergic Receptors
- Agouti and Agouti Related Protein
- Animal Models of Obesity
- Animal QTLs (Quantitative Trait Locus)
- Bardet-Biedl Syndromes
- Cannabinoid Receptor
- CD36 and FAT (Fatty Acid Transporters)
- Cholecystokinin (CCK)
- Cortisol
- Cushing Syndrome
- Cytokines
- Db/Db Mouse
- Dopamine Receptor
- Down's Syndrome
- Epistatic Effects of Genes on Obesity
- Estrogen-Related Receptor
- Familial Lipodystrophies
- Fatty Acid Transport Proteins
- G-Protein Coupled Receptors
- Genetic Taste Factors
- Ghrelin
- Glucagon Receptor
- Glucocorticoids
- Glucokinase
- Growth Hormone
- HDL Receptors
- Histamine Receptor
- Hormone Sensitive Lipase
- Human QTLs
- Hypothyroidism
- Insulin and Insulin Resistance
- Insulin-Like Growth Factors
- Interleukins
- Intrauterine Growth Restriction
- LDL Receptors
- Leptin
- Leptin Receptors
- Lipoprotein Lipase
- Low Birth Weight
- Melanocortins
- Mendelian Disorders Related to Obesity
- Metabolic Rate
- Monogenic Effects that Result in Obesity
- Neuropeptides
- NPY (Neuropeptide Y)
- Ob/Ob Mouse
- Obesity and the Immune System
- Obesity Gene Map
- Opioid Receptor
- Perilipins
- POMC (Proopiomelanocortin)
- PPAR (Peroxisome Proliferator-Activated Receptors)
- Prader-Willi Syndrome
- Protein Kinase
- Set or Settling Point
- Steroids
- Thrifty Gene Hypothesis
- Thrifty Gene Hypothesis and Obesity
- Thyroid Hormone
- TNF (Tumor Nucrosis Factors)
- Transgenics and Knockouts for Obesity-Related Genes
- Tubby Candidate Gene
- Twin Studies and Genetics of Obesity
- Uncoupling Proteins
- Viral Causes of Obesity
- Children and Obesity
- Advertising
- Atherosclerosis in Children
- Bariatric Surgery in Children
- Behavioral Treatment of Child Obesity
- Beverage Choices in Children and Obesity
- Breastfeeding
- Changing Children's Food Habits
- Childhood Obesity as a Risk Factor for Adult Overweight
- Childhood Obesity Treatment Centers
- Children and Diets
- Ethnic Disparities in the Prevalence of Childhood Obesity
- Family Behavioral Interventions
- Family Therapy in the Treatment of Overweight Children
- Flavor Programming and Childhood Food Preferences
- Food Intake Assessments in Children
- Formation and Development of Food Preferences
- Genetic Taste Factors
- Hypertension in Children
- Implications of Restriction of Foods on Child Feeding Habits
- Medical Interventions for Children
- Metabolic Disorders and Childhood Obesity
- Morbid Obesity in Children
- National Weight Loss Efforts for Children
- Overweight Children and School Performance
- Overweight Children and the Media
- Peer Influences on Obesity in Children
- Pharmacological Treatment of Childhood Obesity
- Physical Activity in Children
- Prevalence of Childhood Obesity in Developing Countries
- Prevalence of Childhood Obesity in the United States
- Prevalence of Childhood Obesity Worldwide
- Prevention
- School-Based Interventions to Prevent Obesity
- Self-Esteem and Children's Weight
- Stigmas against Overweight Children
- Type 2 Diabetes
- Dietary Interventions to Treat Obesity
- Atkins Diet
- Calcium and Dairy Products
- Caloric Restriction
- Carbohydrate “Addictions”
- Chromium Picolinate
- Diet Myths
- Dietary Restraint
- Exercise
- Fast Foods
- Fiber and Obesity
- Fruits and Vegetables
- High-Carbohydrate Diets
- High-Protein Diets
- Jenny Craig
- L.A. Weight Loss
- Liquid Diets
- Low-Calorie Diets
- Low-Fat Diets
- Macrodiets
- Medifast
- Non-Diet Approaches
- Nutrisystem
- Nutrition Fads
- Optifast
- Physical Activity and Obesity
- Portion Control
- Slim-Fast
- South Beach Diet
- Supplements and Obesity
- Vegetarianism
- Very Low-Calorie Diets
- Volumetrics
- Water and Obesity
- Weight Watchers
- Zone, The
- Disordered Eating and Obesity
- Anorexia Nervosa
- Antidepressants
- Appetite Signals
- Binge Eating
- Body Dysmorphic Disorder
- Body Image
- Bulimia Nervosa
- Childhood Onset Eating Disorders
- Cognitive-Behavioral Therapy
- Depression
- Dieting: Good or Bad?
- Disinhibited Eating
- DSM-IV
- Eating Disorders and Athletes
- Eating Disorders and Gender
- Eating Disorders and Obesity
- Eating Disorders in School Children
- EDNOS
- Families of Eating Disorder Patients
- Feminist Perspective and Body Image Disorders
- Genetic Influences on Eating Disorders
- Hunger
- Neurotransmitters
- Night Eating Syndrome
- Physiological Aspects of Anorexia
- Physiological Aspects of Bulimia
- Prevalence of Disordered Eating
- Sexual Abuse and Eating Disorders
- Treatment Centers for Eating Disorders
- Weight Cycling and Yo-Yo Dieting
- Environmental Contributors to Obesity
- Accessibility of Foods
- Advertising of Foods to Children
- Children's Television Programming
- Economics of Food
- Energy Density
- Fast Foods
- Food Advertising
- Food Labeling
- Governmental Subsidizing of Energy Dense Foods
- Inaccessibility of Exercise
- Increased Reliance on Automobiles
- Increasing Portion Sizes
- Palatability
- Parental and Home Environments
- Safe Play Opportunities for Children
- School Lunch Programs
- Schools and Obesity
- Sodas and Soft Drinks
- Sugar and Fat Substitutes
- Supersizing
- Television
- Toxic Environment
- Health Implications of Obesity
- Appetite Control
- Asthma
- Atherosclerosis
- Back Pain
- Blood Lipids
- Body Image
- Breast Cancer
- Colon Cancer
- Congestive Heart Failure
- Depression
- Elevated Cholesterol
- Fatty Liver
- Fertility
- Fitness
- Gallbladder Disease
- Gastroesophageal Reflux (GERD)
- Gastrointestinal Disorders
- Gestational Diabetes
- Gout
- High-Density Lipoproteins
- Hormones
- Hypertension
- Impotence
- Kidney Failure
- Kidney Stones
- Low-Density Lipoproteins
- Menstrual Problems
- Mortality and Obesity
- Osteoarthritis
- Osteoporosis
- Ovarian Cancer
- Ovarian Cysts
- Overall Diet Quality
- Polycystic Ovary Disease
- Respiratory Problems
- Sexual Health
- Sleep Apnea
- Stroke
- Type 2 Diabetes
- Urinary Incontinence in Severe Obesity in Women
- Uterine Cancers
- Medical Treatments for Obesity
- American Medical Association
- American Obesity Association
- Amphetamines
- Caffeine
- Cost of Medical Obesity Treatments
- Dexatrim
- Dieting: Good or Bad?
- Ephedra
- Fenfluramine
- Future of Medical Treatments for Obesity
- Gastric Bypass
- Gastroplasty
- Health Coverage of Gastric Surgeries
- International Obesity Task Force
- Laparoscopy
- Liquid Diets
- Low-Calorie Diets
- Medical Interventions for Children
- Medications that Affect Nutrient Partitioning
- Multidisciplinary Bariatric Programs
- Noradrenergic Drugs
- North American Association for the Study of Obesity
- Orlistat (Xenical)
- Physician-Assisted Weight Loss
- Qualifications for Gastric Surgery
- Roux-en-y Gastric Bypass
- Serotonergic Medications
- Sibutramine (Meridia)
- Thyroid Medications
- Vertical Banded Gastroplasty
- Very Low-Calorie Diets
- New Research Frontiers on Obesity
- Acomplia
- Bioelectrical Impedance Analysis
- Bod Pod and Pea Pod
- CART Peptides
- Combined Approaches to Treatment
- Computerized Tomography
- DEXA (Dual Energy X-ray Absorptiometry)
- Dilution Techniques
- Doubly Labeled Water
- Drug Targets that Decrease Food Intake/Appetite
- Drugs that Block Fat Cell Formation
- Energy Expenditure Technologies
- Food Technology
- Frontiers in Maintenance and Prevention
- Functional Foods
- Functional Magnetic Resonance Imaging
- Genetic Mapping of Obesity-Related Genes
- Genomics
- Histamines
- Hormone Disorders
- Hydrodensitrometry
- Indirect Calorimetry
- Intestinal Microflora Concentrations
- Leptin Supplements
- Magnetic Resonance Imaging Scans for Viewing Body Composition
- Metformin
- Microarray Analysis
- New Candidate Obesity Genes
- New Drug Targets that Prevent Fat Absorption
- New Drug Targets to Improve Insulin Sensitivity
- New Drug Targets to Increase Metabolic Rate
- Non-Diet Approaches
- Obesity and Viruses
- Quantitative Trait Locus Mapping
- Rimonabant
- SNP Technologies
- Three-D Image Reconstruction
- Translational Research
- Whole-Body Potassium Counting
- Obesity and Ethnicity/Race
- African Americans
- Asian Americans
- Body Fat Distribution in African Americans
- Body Fat Distribution in Asian Americans
- Body Fat Distribution in Hispanic Americans
- Cardiovascular Disease in African Americans
- Cardiovascular Disease in Asian Americans
- Cardiovascular Disease in Hispanic Americans
- Caucasians
- Dominican Americans
- Ethnic Variations in Body Fat Storage
- Ethnic Variations in Obesity-Related Health Risks
- Genetics
- Health Disparities—NIH Strategic Plan
- Hispanic Americans
- Hypertension in African Americans
- Hypertension in Asian Americans
- Hypertension in Hispanic Americans
- Mexican Americans
- Native Americans
- Obesity and Socioeconomic Status
- Pima Indians
- Puerto Rican Americans
- Sisters Together
- Thrifty Gene Hypothesis
- U.S. Office of Minority Health
- Western Diets
- Obesity and the Brain or Obesity and Behavior
- Antidepressants
- Appetite Control
- Autonomic Nervous System
- Bombesin
- Cannabinoid System
- Central Nervous System
- Cholecystokinin
- Conditioned Food Preferences
- Corticotropin-Releasing Hormone
- Dopamine
- Drugs and Food
- Fat Taste
- Flavor: Taste and Smell
- Folic Acid and Neural Tube Defects
- Food “Addictions”
- Food Reward
- Gustatory System
- Habituation
- Hypothalamus
- Inherited Taste Preferences
- Insulin
- Liking vs. Wanting
- Medications that Increase Body Weight
- Mood and Food
- Neuropeptide-Y
- Neurotransmitters
- Norepinephrine
- Nutrient Reward
- Olfactory System
- Opioids
- Oxytocin and Food Intake
- Peripheral Nervous Sytem
- Pituitary Gland
- Satietin
- Sensory-Specific Satiety
- Sweet Taste
- Sympathetic Nervous System
- Taste Aversion Learning
- Taste Reactivity
- Thyroid Gland
- Tryptophan
- Obesity as a Public Health Crisis
- Access to Nutritious Foods
- American Academy of Pediatrics
- American College of Sports Medicine
- American Diabetes Association
- American Dietetic Association
- American Heart Association
- American Medical Association
- American Obesity Association
- American Society for Bariatric Surgery
- Built Environments
- Center for Maternal and Child Health
- Center for Nutrition Policy and Promotion
- Center for Science in the Public Interest
- Centers for Disease Control and Prevention
- Child Obesity Programs
- Community Level Initiatives to Prevent Obesity
- Community Programs to Prevent Obesity
- Council on Size and Weight Discrimination
- Economics of Obesity
- Expanded Food and Nutrition Program
- Federal Initiatives to Prevent Obesity
- Food and Drug Administration
- Food Guide Pyramid
- Food Labeling
- Food Marketing to Children
- Food Stamp Nutrition Education Program
- Government Agencies
- Head Start
- Healthy Eating Index
- Healthy People 2010
- National Association to Advance Fat Acceptance
- National Cancer Institute
- National Center for Health Statistics
- National Eating Disorders Association
- National Heart, Lung, and Blood Institute
- National Institutes of Health
- NIDDK
- North American Association for the Study of Obesity
- Obesity in Schools
- Office of Dietary Supplements
- Office of Minority Health
- Policy to Prevent Obesity
- President's Council on Physical Fitness and Sports
- Safety of Urban Environments
- School Initiatives to Prevent Obesity
- Shape-Up America!
- Social Marketing and Obesity
- State and Local Initiatives to Prevent Obesity
- Taxation of Unhealthy Foods
- Toxic Environment
- U.S. Department of Agriculture
- U.S. Department of Health and Social Services
- Weight Control Information Network
- Psychological Influences and Outcomes of Obesity
- Addictive Behaviors
- Anorexia Nervosa
- Anxiety
- Binge Eating
- Bulimia Nervosa
- Cognitive-Behavioral Therapy
- Compulsive Overeating
- Depression
- Disordered Eating
- Eating Disorders in School Children
- External Controls
- Loneliness
- Night Eating Syndrome
- Obsessive Compulsive Disorder
- Psychiatric Medicine and Obesity
- Self-Esteem and Obesity
- Stress
- Suicidality
- Well-Being
- Societal Influences and Outcomes of Obesity
- Alcohol
- Appearance
- Body Image
- Breastfeeding vs. Formula Feeding
- Built Environments
- Calcium Intake and Dairy Products
- Carbohydrate and Protein Intake
- Computers and the Media
- Eating Out in the United States
- Fat Acceptance
- Fat Intake
- Flavor Learning
- Food Advertising and Obesity
- Food Guide Pyramid
- Food Intake Patterns
- Food Labeling
- Food Preferences
- Governmental Policy and Obesity
- Income Level and Obesity
- Nutrition Education
- Obesity and Academic Performance
- Obesity and Drug Use
- Obesity and Sports
- Obesity and the Media
- Obesity in Schools
- Personal Relationships and Obesity
- Physical Activity Patterns in the Obese
- Smoking
- Soda and Soft Drink Intake
- Stereotypes and Obesity
- Supersizing
- Variety of Foods and Obesity
- Virtual Environments
- Weight Discrimination
- Western Diet
- Women and Dieting
- Women and Obesity
- Assessment of Obesity and Health Risks
- Bariatric Surgery in Women
- Body Image
- Breast Cancer
- Breastfeeding
- Colon Cancer
- Coronary Heart Disease in Women
- Early Onset Menarche and Obesity in Women
- Economic Disparities among Obesity in Women
- Endometrial and Uterine Cancers
- Estrogen Levels
- Ethnic Disparities among Obesity in Women
- Exercise and Physical Activity among Obese Women
- Fat Acceptance
- Fertility
- Food Preferences
- Gestational Diabetes
- Implications of Gestational Development
- Maternal Influences on Child Feeding
- Menopause and Obesity
- Morbid Obesity in Women
- Obese Women and Social Stigmatization
- Polycystic Ovary Disease
- Pregnancy Prevalence of Obesity in U.S. Women
- Self-Esteem in Obese Women
- Support Groups for Obese Women
- Waist-to-Hip Ratio
- Women and Diabetes
- Women and Dieting
- Worldwide Prevelance of Obesity
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