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Medical decision making at the organizational and societal levels usually requires that health benefits be quantified in a common unit. This enables administrators or decision makers to compare and evaluate programs that address different diseases or populations. To compare very different alternatives, measures of program benefits must be comprehensive, including all possible direct effects, whether intended or not. Therefore, the current consensus is that preference- or utility-based measures of generic health-related quality of life (HRQOL) best meet these criteria. The most frequently used measures in this class include the EuroQOL 5D (EQ-5D), the Health Utilities Index measures (HUI), and the Quality of Well-Being Scale measures (QWB and QWB-SA).

The Quality of Well-Being (QWB) scale is a generic, preference-based measure of HRQOL with well-established psychometric properties in a wide variety of diseases and subgroups. In response to limitations of the QWB, a self-administered version of the QWB (QWB-SA) has been developed and validated. The QWB-SA is quicker and easier to administer in most research and clinical assessment protocols. Both questionnaires assess the presence or absence of symptoms and functioning on specific days prior to administration. The measures produce a single score that ranges from 0 (death) to 1.0 (optimal HRQOL). The final score from the QWB-SA or the QWB can be integrated with time and mortality to calculate quality-adjusted life years (QALYs) and conduct cost-effectiveness analysis.

Health-Related Quality of Life

Health-related quality of life (HRQOL) provides a comprehensive description of health and overall well-being. HRQOL measures can be classified in a number of different ways. For example, HRQOL measures are either generic or disease-specific and can be described as psychometrically based or preference/utility based. The QWB (and QWB-SA) is a generic HRQOL measure that was designed to be used with any adult population and any health condition, including healthy individuals. The QWB and QWB-SA are preference-based measures and were not developed to assess statistically independent domains of HRQOL. They provide a single score that summarizes total HRQOL based on the mean preference ratings that health consumers gave to the health states described within it. These preferences or utilities are ratings of observable health states using a scale anchored by death and optimum health, and assuming equal intervals.

Theoretical Basis

The QWB was developed in the 1970s based on a General Health Policy model. This theoretical model focuses on mortality (death) and morbidity (health-related quality of life) and proposes that symptoms and disabilities are important for two reasons: First, illness may cause life expectancy to be shortened and, second, illness may make life less desirable at times prior to death. In assessing the impact of medical interventions or programs, the model requires data on changes in mortality as well as on changes in HRQOL. The General Health Policy model incorporates preference for observed health states (utility) and duration of stay in health states. Preferences or utility for health states are typically measured using economic principles that ask individuals to place preferences or values on a wide variety of health states involving both symptoms and functioning. The health preferences or utilities are placed on a preference continuum for the desirability of various health states, giving a “quality” rating on an interval scale ranging from 0 for death to 1.0 for completely well.

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