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Variability is the extent to which measurements differ from one another. Understanding the variability in a sample or population is important to evaluating whether an observed outcome is meaningful in a statistical analysis. Using the variability, researchers can identify whether a change in a measure is larger than what would be expected by chance. In addition, when reviewing data about a treatment or intervention, the average patient outcome may be less important than the range of likely outcomes. Frequently reported measures of variability include variance, standard deviation, standard error, coefficient of variation, and interquartile range. Graphs and plots of data may be useful for illustrating variability and guiding statistical analyses.

Variance and Standard Deviation

Among the most common measures of variability is the variance, σ2, which is a function of the differences between each data point and the average (mean) of the data. Larger variances indicate more variability (see Figure 1, which shows the difference in variability for two groups with identical means when σ2 = 1 and σ2 = 9). The variance is always greater than or equal to 0: If all the values are identical, σ2 = 0. While the variance is affected if each measurement in the data is multiplied by the same number (change in the scale), it is not changed if the same number is added to each measurement (shift in location). Another useful property of the variance is that the variance of a sum of uncorrelated measures is equal to the sum of their variances.

The variance of a population may be estimated from a sample of size n using the unbiased estimator

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, where X1, …, Xn is a random sample and
None
is the sample mean. The biased version, σ2 which replaces the denominator, n — 1, with n, is less commonly used. As an example, Table 1 gives the birth weights of 12 male and 12 female infants in kilograms. The mean birth weight for males in this sample is
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= 3.48, and the sample variance is s2 = .26. For females, the sample mean is
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= 3.30, and the sample variance is s2 = .15.

The standard deviation, σ or SD, is the square root of the variance and is often used with the average to describe the distribution of a measure. It is greater than or equal to 0 and is measured in the same units as the measure of interest, which is useful for interpretation. The sample standard deviation, s, the square root of the sample variance, s2, is used in many formulas for confidence intervals and hypothesis testing. In Table 1, s = .51 for males and 39 for females. When estimating the combined (pooled) standard deviation from more than one group or sample, the following formula is often used:

Figure 1 Comparison of different variability measures

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Note: Scatterplot of random samples from normal distributions with mean 0 with variance equal to 1, and mean 0 with variance equal to 9.

Table 1 Birth weight (kg) of full-term male and female infants
MalesFemales
4.13.43.83.1
3.53.22.83.6
3.33.03.83.8
4.03.23.43.0
3.72.73.42.7
4.53.23.03.2

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