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Discrete-event simulation (DES) is a very flexible modeling method that can be used when the research question involves competition for resources, distribution of resources, complex interactions between entities, or complex timing of events. The main advantage and disadvantage of DES is its large but constrained modeling vocabulary. That is, though there is more to learn initially, there is more freedom regarding the kinds of systems one can model.

DES was originally developed in the 1960s to model industrial and business processes, finding its first home in industrial engineering and operations research. Since then, DES has been used to gain insight into a wide range of research and business questions. Because of its unique strengths, DES began to be applied to healthcare problems in the mid-1980s.

Since its introduction, DES has been used to examine a broad array of healthcare and healthcare-related problems. Areas in which it has been applied have been mental health; disease management; infectious disease; disaster planning and bioterrorism; biology model and physiology; cancer; process redesign and optimization in laboratories, clinics, operating rooms, emergency services, healthcare systems, and pathways of care; geographic allocation of resources; trial design; policy evaluation; and survival modeling. DES is often the preferred simulation method in healthcare when (a) there is competition for resources, (b) systems are tightly coupled, (c) the geographic distribution of resources is important, (d) information or entity flow cannot be completely described a priori, (e) the timing of events may be asynchronous or cannot be modeled on a fixed clock, and (f) entities in the system require memory.

Simulation Modeling

In general, models allow researchers to explicitly explore the elements of a decision/problem and mediate understanding of the real world by rendering it comprehensible. Simulation modeling is any activity where the actual or proposed system is replaced by a functioning representation that approximates the same cause-and-effect relationship of the “real” system. Simulation allows researchers to generate evidence for decision making or to develop understanding of underlying processes in the real world when direct experimentation (due to cost, time, or ethics) is not possible. Experimentation with simulation models is performed through sensitivity analyses, where the parameters of the system are varied, or through what-if experiments, where the number or types of resources of the system are varied.

Decision trees and Markov models have, to date, been the most common types of computer simulation models used in healthcare. These methods are used to create highly structured representations of decision processes and alternative strategies. This is done by constraining the formulation of these models to a limited vocabulary, essentially three building blocks—decision nodes, chance nodes, and outcome nodes. The main advantage of this type of formulation is that the highly structured format is relatively transparent and easy to interpret. The disadvantage is that the highly structured framework restricts the types or problems that can be articulated, often forcing significant compromises on the model and the modeler. With over 100 building blocks, DES has a much broader vocabulary (than tree models), allowing a broader array of problems to be modeled, with fewer compromises. This means that though there is more to learn initially there, is a greater range of problems one can model.

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