Skip to main content icon/video/no-internet

The statement that exercise is good for you is, in the 21st century, noncontroversial. The volume and quality of data that demonstrate the positive health outcomes associated with either an active lifestyle or with systematic exercise training in either healthy individuals or those with cardiovascular disease is substantial. This concept is supported by an organizational theme used by the American College of Sports Medicine, “Exercise Is Medicine,” which suggests that the health impact of regular exercise is of the same order of magnitude as the benefits of pharmacological therapy for hypercholesterolemia, hypertension, and smoking cessation. Guidelines, whether for habitual activity or structured exercise training, have been widely accepted, and there are extensive public health recommendations regarding exercise training.

However, regardless of the benefits of exercise, there is an appreciable risk of significant morbidity and mortality during exercise. Because complications during exercise represent a “man bites dog” situation, they are highly visible and widely reported. The topic has been the subject of a recent Scientific Statement from the American Heart Association, in collaboration with the American College of Sports Medicine. The risk of exercise must be interpreted against the context of classic data from the Framingham heart study demonstrating that the first presentation of cardiovascular disease is fatal in 33% of men and 10% to 15% of women. Thus, the risk of exercise, which might serve to provoke the presentation of cardiovascular disease, is not trivial and health care professionals must consider the best ways to help individuals achieve the benefits of exercise while minimizing the risk of complications.

Substrate for Exertional Complications

Exercise-related complications are usually observed in individuals with structural heart disease. In younger individuals, the structural heart disease is usually limited to congenital abnormalities, primarily hypertrophic cardiomyopathy; however, other common abnormalities include coronary artery abnormalities, aortic stenosis, mitral valve prolapse, aortic dissection/rupture, arrhythmogenic right-ventricular cardiomyopathy, and long QT syndrome. Myocarditis is also associated with exertion-related morbidity/mortality in young individuals. With the exception of aortic dissection/rupture associated with Marfan syndrome, most of the deaths in young individuals are arrhythmic in origin and present suddenly. Commotio cordis (disruption of the heart rhythm due to chest wall trauma) is most commonly seen in young athletes (e.g., after being struck with a baseball or hockey puck directly over the heart) and can provoke sudden death.

In older individuals, exertion-related complications can result from congenital abnormalities but more typically are related to the sequelae of atherosclerotic coronary artery disease. The usual age of demarcation of “older” is 40 years, although some individuals with inherited lipoprotein abnormalities can develop atherosclerotic disease quite early in life. Although autopsy studies from deaths occurring in soldiers killed in combat have indicated that individuals in their late teens and early 20s may have significant atherosclerotic disease, it is comparatively rare for atherosclerotically mediated exertion-related complications to present prior to age 40.

Mechanisms of Sudden Death

In adults who have been asymptomatic, the most common mechanism of exertion-related complications is rupture of atherosclerotic plaques, leading to rapid thrombus formation and near-total occlusion of the affected coronary artery downstream from the plaque. Lesions of moderate severity, with a relatively lipid-rich matrix under the atherosclerotic plaque, are more likely to rupture. More mature lesions and/or high-grade lesions may contribute to exertional angina pectoris or may lead to slow thrombus formation, but they are comparatively less likely to provoke the sudden events that provoke acute myocardial infarction during exercise.

...

  • Loading...
locked icon

Sign in to access this content

Get a 30 day FREE TRIAL

  • Watch videos from a variety of sources bringing classroom topics to life
  • Read modern, diverse business cases
  • Explore hundreds of books and reference titles

Sage Recommends

We found other relevant content for you on other Sage platforms.

Loading