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Medical geography applies the concepts and techniques of geography to the study of disease and health. It is one of the most practical subdisciplines of human geography in that it seeks to address issues that are clearly of vital concern to people in their daily lives. It is concerned with issues such as the spatial distribution of breast cancer mortality rates, the pattern of diffusion of influenza, the effect of people's movements on the spread of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), the geography of toxic hazards, why hospitals are located where they are, and comparisons of the distances people must travel to primary healthcare in urban and rural areas. Although medical geography traces its origins to the Greek physician Hippocrates (ca. 460–377 BC), it only became a recognized field of study during the 18th century. Its recent flourishing began with the publication of Jacques May's series of global disease and nutrition maps during the early 1950s.

Medical geographers examine health and disease in the context of both a variety of cultures around the world and a variety of physical environments. They must be familiar with other fields of study within the natural sciences, the social sciences, medicine, and public health. Depending on their specific interests, those aspiring to become medical geographers should have a thorough grounding in cultural ecology, climatology, virology, epidemiology, health policy, biostatistics, anthropology, and geographic information systems (GIS), among other areas. Traditionally, medical geography has been divided into two main subcategories, disease ecology and healthcare delivery, although these two concerns are interrelated. A third subcategory, spatial analysis, always has been vital to medical geography and has become more so with the use of GIS.

Disease Ecology

Disease ecologists examine the effects of disease on the triangle of human ecology, which consists of (a) habitat (the physical environment in which people live), (b) population (human characteristics such as gender and age), and (c) behavior (the actions of people). Within this framework, a wide variety of human ailments have been examined. The study of transmissible diseases, most important in the developing world, entails looking at the complex relationships among organisms that create the disease (agents), humans who may be infected (hosts), organisms that transmit the disease (vectors), and animal hosts (reservoirs). For example, African trypanosomiasis (or sleeping sickness), endemic in large areas of tropical Africa, is caused by the agents Trypanosoma gambiense and Trypanosoma rhodesiense, vectored by the tsetse fly, and has wild game and cattle as a reservoir.

The most important diseases in most of the developed world are degenerative and chronic diseases, including various cancers, heart disease, and stroke. These diseases usually are caused by a wide range of factors that disease ecologists need to examine such as genetic predisposition, radiation levels, water pollution levels, diet and exercise regimes, income levels, migration patterns, and social integration levels. Disease ecologists have also been at the forefront in investigating the spread of diseases that are transmitted through close human contact or through the air or water. A good example is a geographic study of the diffusion of cholera in the United States in 1832.

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