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Open-Ended Study
An open-ended study does not have a defined end point, such as a fixed dose quantity, but allows the ending to be determined based on the patient's response to therapy.
One type of open-ended study involves an escalating dose schedule, for example, according to a modified Fibonacci sequence. This type of study is very common in cancer clinical trials.
Here dose escalation is terminated when dose-limiting toxicity (DLT) is seen in over 50% of cases. The maximum tolerated dose (MTD) is defined as one level below the DLT. Further (phase 2) studies are usually planned at 80% of MTD. Phase 1 studies commonly have no benefit to the patient treated, and efficacy data (if any) should be used only to plan further studies.
10.4135/9781412950602.n554
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- Provider
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- Employee Rights
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- Ethical Issues Faced by Managers
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- Excess Liability Coverage
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- Exposure
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- Federal Regulating Agencies
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- Tail Coverage
- Title VII of the Civil Rights Act of 1964
- Unanticipated Outcome Disclosure
- Vicarious Liability
- Women, Infants, and Children (WIC) Program
- Managed Care
- Ambulatory Care
- Carve-Out
- Compensating Differentials
- Enrollee
- Enrollment
- Evidence-Based Medicine
- Fee-for-Service
- Health Care Reform
- Health Maintenance Organizations (HMOs)
- Length of Stay
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- Medical Care
- Out-Of-Network Services
- Patterns of Care
- Per Diem Payments
- Per Member Per Month (PMPM)
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- Marketing and Customer Value
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- Customer
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- Customer Satisfaction Research
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- Maintenance of Scope
- Market Entry Strategies
- Market Opportunity Analysis
- Market Segmentation
- Marketing Concept
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- Marketing Plan
- Marketing Research
- Marketing Value
- Mass Customization
- Mystery Shoppers
- Non Price Competition in Hospitals
- One-to-One Marketing
- Patient Expectations
- Perceptual Gaps in Services Quality
- Physician-Patient Relationship
- Press Releases
- Product
- Product Classes
- Product Life Cycle (PLC) Analysis
- Product Line Extensions
- Product Mix
- Public Relations
- Sales Forecasting
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- Services
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- Wellness
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- Operations and Decision Making
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- Clinical Decision Making
- Decentralization of Decision Making
- Decision
- Decision Support Systems
- Economic Order Quantity (EOQ)
- Empowerment (Delegation of Authority)
- Enterprise Resource Planning
- Excess Capacity
- Facilities Management
- Future Search
- Geographic Information System
- Health Care Service Operation
- Health Production Functions
- Just In Time and Health Care Management
- Mass Customization
- Nominal Group Technique (NGT)
- Operations Management
- Outsourcing
- Production Possibilities Curve
- Queuing
- Root Cause Analysis
- Sales Forecasting
- Service Operation
- Statement of Operations
- Supply Chain Management
- Technology Assessment
- Technology Change
- Theory of Constraints
- Utilization Review
- Value Chain for Health Care
- Waiting Time
- Pharmaceuticals and Clinical Trials
- Adverse Drug Reaction (ADR)
- Adverse Event (AE)
- Adverse Selection and Impact
- Alternative Medicine (Complementary Medicine, Integrative Medicine, Unconventional Medicine)
- Assurance
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- Biotechnology
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- Price Control in the Pharmaceutical Industry
- Protocol (Involving Human Subjects)
- Quality Assurance
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- Recruitment
- Standard Operating Procedures (SOPs)
- Standard Treatment
- Study Arms
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- Subject, Human Research
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- Vulnerable Research Subject Population
- Quality
- Academic Degrees
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- Common Cause Variation
- Continuous Quality Improvement (CQI)
- Control Chart
- Disease Management
- Electrocardigram (EKG or ECG)
- Flowchart
- Global Blood Safety Projects
- Health Status Indicators
- Hippocratic Oath
- Length of Stay
- Maternal and Child Health
- Medical Care
- Medical Errors
- Morbidity
- Mortality
- National Committee on Quality Assurance (NCQA)
- Outcomes Research
- Pareto Chart
- Patterns of Care
- Plan-Do-Study-Act Cycle
- Quality Assurance
- Quality Improvement Cycle
- Quality Management
- Root Cause Analysis
- Run Chart
- Service Quality
- Six-Sigma Program
- Special Cause Variation
- Statistical Process Control (SPC)
- Statistical Thinking
- Supply Chain Management (SCM)
- Utilization Review
- Wellness
- Zero Defects
- Statistics and Data Mining
- Strategy
- Alliances
- Authority
- Balanced Scorecard
- BCG Portfolio Analysis
- Boards of Directors
- Breakeven Analysis
- Business Plan
- Co-opetition
- Coalitions
- Collaborative Partnership
- Competitive Advantage
- Competitive Strategy and Groups
- Contraction Strategy
- Cooperation Strategies
- Critical Success Factors
- Culture and Culture Change
- Culture and Strategy
- Diversification Strategies
- Divestiture Strategies
- Emergent Strategy
- Environmental Analysis
- Expansion Strategies
- Generic Strategies
- Harvesting Strategies
- Horizontal Integration
- Industry Analysis
- Internal Environmental Analysis
- Long-Range Planning
- Managed Competition
- Managing Organizational Change
- Market Entry Strategies
- Merger and Acquisition
- Mission
- Networks
- Niche Strategies
- Nonprice Competition in Hospitals
- Objectives
- Organizational Change
- Organizational Design and Discontinuous Change
- Product Life Cycle Analysis
- Service Area Competitor Analysis
- Strategic Alternatives
- Strategic Assumptions
- Strategic Business Units (SBU)
- Strategic Change
- Strategic Control
- Strategic Decision
- Strategic Fit
- Strategic Group
- Strategic Issue Diagnosis (SID)
- Strategic Leadership
- Strategic Management
- Strategic Management Process
- Strategic Service Unit (SSU)
- Strategic Thinking
- Strategy
- Structure
- Subsidiary Corporations
- SWOT (Strength-Weakness-Opportunity-Threat) Analysis
- Synergy
- Value Chain for Health Care
- Values (Guiding Principles)
- Vertical Integration
- Vision
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