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Drugs and Pharmaceuticals
Among the most rapidly advancing global technologies, pharmaceuticals are at the center of global struggles for human rights, health, trade, and human connectivity. Drugs and pharmaceuticals are important in two significant ways for global studies: (1) The development, production, and regulation of legal drugs and pharmaceuticals are producing new global forms of quality assurance and protection for intellectual property, and (2) drugs and pharmaceuticals have been the catalyst for the mobilization of a transnational social movement around issues of global access.
Globalization processes have been linked to increasing epidemics of diet or lifestyle diseases (e.g., diabetes, heart disease, lung disease, and asthma) in rich countries and infectious diseases (e.g., HIV/AIDS, tuberculosis, and malaria, often referred to simply as “the three diseases” as a statement of their impact on global health) in poor countries. The causal links between global processes and disease vectors are complex and not unidirectional (proving that the links between globalization and disease remain more ideological than empirical). Still, given the progress in drug development, nutrition, and hygiene, levels of morbidity (sickness) and mortality remain much higher than expected. Understanding why this is the case is important for understanding global processes.
Spending on pharmaceuticals alone accounts for more than 15% of measured total global spending on health. The development of new drugs, including testing in clinical trials, and distribution of existing ones are genuinely global in scope. Struggles over access to good quality drugs have mobilized political action in countries as diverse as Brazil, South Africa, and the United States. Yet, most significantly for global studies, these movements have not drawn support primarily from national citizens but from transnational linkages between citizens who communicate and act using new media and global communications.
Understanding the economics and politics of how pharmaceuticals is linked to how drugs, or the lack of them, influence people's everyday lives. João Biehl's work on Brazil documents how what he calls the “pharmaceuticalization” of governance and citizenship creates new forms of inequality between those who have access to drugs and those who do not. In the process, this pharmaceuticalization highlights the deficiencies in the national health care structures as well as the poverty and inequality among citizens. Today, drugs and pharmaceuticals are technologies with implications for individual health and for social, economic, and political well-being.
Drug Development and Production
The modern pharmaceutical industry can be traced to the 19th-century isolation and mass production of powerful compounds such as cocaine, morphine, nicotine, quinine, and strychnine. Around the time of World War II, scientific breakthroughs made penicillin and other antibiotics available to treat devastating and previously untreatable diseases such as tuberculosis. By the mid-20th century, thousands of drugs had been patented. At this time, pharmaceutical companies were already operating internationally for licensing and marketing agreements, subsidiaries, and joint ventures. Today, medicine production is highly concentrated in the industrialized countries, where just five countries—the United States, Japan, Germany, France, and the United Kingdom—account for two thirds of the value of all medicines produced. They dominate by value largely because they produce expensive, branded drugs to treat diseases that occur in populations of customers who can pay for them. However, large-volume markets of lower priced medicines also exist in the highly competitive domestic markets of countries such as Brazil, Thailand, China, and India. In these countries, a growing number of producers manufacture the bulk of generic drugs in global distribution, but they are also beginning to compete in high-value pharmaceutical production through exports. Still, a small number of transnational companies dominate the global production, trade, and sales of medicines. Ten of these companies now account for almost half of all sales. This concentration has increased considerably since a rapid boom began in 1987. Overall, the global pharmaceutical trade has experienced unprecedented growth since around 1985 and continues to grow. The market value of global pharmaceuticals had a compound annual growth rate from 2002 to 2006 of 6.6%, and it remains one of the highest profit industries in the world, according to the global pharmaceutical industry.
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