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Kidney, or renal failure is the loss of the ability of the kidney to eliminate waste and excess material from the bloodstream and to recycle important nutrients back into the blood. Without correctly functioning kidneys, excess fluid and waste products like urea and excess potassium can accumulate to dangerous levels in the body. This process can be acute (suddenly occurring) or chronic (developing overtime). Both types cause damage to the kidneys but are associated with different medical conditions and also have very different disease courses and outcomes. A common treatment for kidney failure is dialysis during which the blood is filtered mechanically to compensate for the nonfunctioning kidneys.

In order to fully grasp the concept of kidney failure it is important to understand what the kidneys do. The kidneys are two bean-shaped organs located in the back of the upper abdomen, one on each side of the spine. They are part of the urinary system. When we eat, our bodies digest proteins and separate them into different substances that are distributed into the bloodstream. The jobs of the kidney are to sort waste materials that cannot be used, or are harmful, out of the bloodstream in order to eliminate them from the body as urine and also to keep substances that are essential for bodily functions, such as vitamins, minerals and electrolytes, in the bloodstream. The kidneys are like a water filter because they both catch and remove pollutants. When a water filter doesn't work, pollutants, or waste, can remain in the water and can cause sickness when consumed. In the same way, when the kidneys don't work, waste material remains in the bloodstream and can harm the body while electrolytes and other useful products are lost in the urine. The kidneys are also responsible for making certain hormones that keep bones healthy and maintain blood counts.

Acute and Chronic Renal Failure

Acute renal failure describes the condition when kidney functions deteriorate rapidly—as quickly as several hours or days. The causes of acute renal failure can be categorized into pre-renal, renal and post-renal depending on where the problem in the system lies. Pre-renal causes are the most common and are generally caused by problems that interfere with blood supply to the kidney, decreasing the amount of oxygen and nutrients needed to work properly. Some examples are low blood pressure from bleeding or dehydration and reduced heart function due to a heart attack or congestive heart failure. Renal causes are those that directly damage kidney structures such as infections of small blood vessels, blood clots, and sudden reactions to medications or toxins that disturb filtration. Post-renal causes are due to interference to parts of the urinary system that take the urine formed in the kidneys and actually eliminate it from the body like obstruction of the bladder from blood clots, stones, or tumors. Essentially, this is much like a clog in a sink drain. If the faucet is running and nothing can get past the clog, the pressure in the drain will build up behind it and eventually flood the sink. Similarly, when the urinary system gets backed up, the kidneys cannot compensate for the extra fluid and are damaged.

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