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Sleep Disorders
An estimated 70 million people in the United States suffer from sleep problems, and more than half of those with sleep problems have a sleep disorder that is chronic. The four most prevalent sleep disorders are insomnia, obstructive sleep apnea, narcolepsy, and periodic limb movements in sleep, with sleep apnea accounting for nearly 80% of all sleep diagnoses in sleep centers in the United States. About 30 million American adults have frequent or chronic insomnia. Approximately 18 million have obstructive sleep apnea, but only 10% to 20% have been diagnosed. An estimated 250,000 people have narcolepsy, and more than 5% of adults are affected by periodic limb movements in sleep syndrome. Sleep disorders have major societal impacts. Each year, sleep disorders, sleep deprivation, and excessive daytime sleepiness (EDS) add approximately $16 billion annually to the cost of health care in the United States and result in $50 to $100 billion annually in lost productivity (in 1995 dollars). According to the National Highway Traffic and Safety Administration, 100,000 accidents and 1,500 traffic fatalities per year are related to drowsy driving. Nearly two thirds of older Americans have sleep difficulties, and the prevalence of sleep problems will increase as the older adult population increases. The 1990s has seen a significant increase in our awareness of the importance of diagnosing and treating sleep disorders. The prevalence rates, risk factors, and treatment options will be reviewed for each of the four major sleep disorders.
Insomnia
Insomnia is the most commonly reported sleep complaint across all stages of adulthood. An estimated 30 million American adults suffer from chronic insomnia, and up to 57% of noninstitutionalized elderly experience chronic insomnia. In the United States, total direct costs attributable to insomnia are estimated at $12 billion for health care services and $2 billion for medications. Emerging evidence suggests that being female and old age are two of the more common risk factors for the development of insomnia; other predisposing factors include excess worry about an existing health condition, lower educational level, unemployment, and separation or divorce. Insomnia is comorbid with anxiety and depressive disorders and may lead to the development of psychiatric disorders. Insomnia is correlated with high levels of medical use and increased drug use, as well as increased psychosocial disruption including poor work performance and poor memory.
Insomnia Treatments
Traditional management of insomnia includes both pharmacologic and nonpharmacologic treatments. Current guidelines suggest that chronic insomnia be treated with a combination of nonpharmacologic interventions, such as sleep hygiene training, relaxation training, stimulus control training, cognitivebehavioral therapy, or sleep restriction/sleep consolidation therapy, and pharmacologic interventions. Medications prescribed for insomnia range from newer agents such as zolpidem, zaleplon, and eszoplicone to older agents such as antidepressants (e.g., amitriptyline or trazodone) and benzodiazepines (e.g., clonazepam, lorazepam). Medications are not typically indicated for long-term treatment of insomnia, except for a medication recently approved by the Food and Drug Administration, eszoplicone.
Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a medical condition characterized by repeated complete (apnea) or partial (hypopnea) obstructions of the upper airway during sleep. It is prevalent in 2% to 4% of working, middleaged adults, and an increased prevalence is seen in the elderly (∼ 24%), veterans (∼ 16%), and African Americans. Being an obese male is the number one major risk factor for OSA. The risk of OSA increases significantly with increased weight, and more than 75% of OSA patients are reported to be more than 120% of ideal body weight. Other risk factors that can contribute to OSA include anatomical abnormalities of the upper airway (e.g., large uvula, enlarged tonsils, large neck circumference). Estimates of health care costs for OSA patients are approximately twice that of matched, healthy controls. This cost difference is evident several years prior to the diagnosis. OSA is associated with a higher mortality rate.
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