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Measles
Measles is a highly contagious viral infection, which prior to the introduction of effective vaccines was a common experience of childhood, sometimes with fatal consequences. Unfortunately, even today not all children receive the vaccine despite its efficacy and availability. In May 2003, the World Health Assembly endorsed resolution WHA56.20 urging Member countries to achieve a goal to reduce global measles deaths by half by end of 2005 compared with the 1999 estimates. Based on results from surveillance data and a natural history model, overall, global measles mortality decreased 48% from an estimated 871,000 deaths in 1999 to an estimated 454,000 deaths in 2004. Many of the recommended World Health Organization (WHO) measles control strategies now in place had been developed and first used during the early 1990s in the Americas, when the countries of the Caribbean and Latin America adopted a multi-tiered vaccination approach combining routine vaccination and mass vaccination campaigns.
Among the WHO regions, the Region of the Americas has had the most success in controlling measles. Starting in 1999, countries throughout the Region of the Americas embarked on accelerated measles elimination activities, using strategies building on the accomplishments of the polio elimination program. Implementing a measles elimination program was clearly an ambitious task, requiring the collaboration of ministries of health, the private sector, nongovernmental organizations, and multilateral and bilateral international partners. The last occurrence of widespread measles virus transmission in the Americas dates to November 2002. Sporadic cases and outbreaks have continued to occur, although 51% of the 370 measles cases reported in the Americas between January 2003 and April 2006 were positively linked to an importation.
Infectious Agent and Transmission
Measles virus is a member of the genus Morbillivirus of the Paramyxoviridae family. The virus appears to be antigenically stable—there is no evidence that the viral antigens have significantly changed over time. The virus is sensitive to ultraviolet light, heat, and drying.
Measles virus is transmitted primarily by respiratory droplets or airborne spray to mucous membranes in the upper respiratory tract or the conjunctiva. Man is the only natural host of measles virus. Although monkeys may become infected, transmission in the wild does not appear to be an important mechanism by which the virus persists in nature.
Measles is highly contagious and is most communicable 1 to 3 days before the onset of fever and cough. Communicability decreases rapidly after rash onset. Secondary attack rates among susceptible household contacts have been reported to be more than 80%. Due to the high transmission efficiency of measles, outbreaks have been reported in populations where only 3% to 7% of the individuals were susceptible.
Prior to the development of effective vaccines, measles occurred worldwide. Presently, in countries that have not embarked on eradication or elimination campaigns or achieved a very high level of sustained measles immunization coverage, the disease still exists. In temperate climates, outbreaks generally occur in late winter and early spring. In tropical climates, transmission appears to increase after the rainy season. In developing countries with low vaccination coverage, epidemics often occur every 2 to 3 years and usually last between 2 and 3 months. Even countries with relatively high vaccination coverage levels may experience outbreaks when the number of susceptible children becomes large enough to sustain widespread transmission.
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