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Lysergic acid diethylamide (LSD) is manufactured from lysergic acid, a substance derived from ergot fungus, which grows on rye and other grains or acid amide. LSD is most commonly taken orally in tablet or capsule form, or ingested on blotter paper. The effects of the drug occur 30 to 90 minutes after ingestion. Common effects include auditory or visual hallucinations, a general feeling of well-being, connection with a “higher power,” or a combination thereof. Synesthesia, a state where one believes he or she is able to taste colors or see sounds, may also occur. At a low dose, LSD is a stimulant.

Other effects of LSD include: dilated pupils, higher body temperature, increased heart rate and blood pressure, loss of appetite, sleeplessness, dry mouth, tremors, numbness, weakness, and nausea. LSD has many street names, including acid, blotter, cid, doses, and trips. Although LSD has a low incidence of abuse, individuals under the influence of LSD may demonstrate weak or unsound judgment, which can lead to fatal accidents. This particular effect has been utilized by governments to regulate manufacturing, distribution, and potential research with LSD. Like heroin and marijuana, LSD is classified as a Schedule I drug in the Controlled Substance Act.

LSD has an interesting history that transcends its discovery and the various policies developed to regulate its use over time. LSD was a cornerstone of the counterculture movement of the 1960s, in which individuals were encouraged to “turn on, tune in, and drop out.”

Discovery and Early Uses

LSD was discovered by accident by Albert Hofmann, who first synthesized it in 1938. That year, Hofmann's intended research program was to discover ergot alkaloid derivatives for medicinal use. Hofmann did not know that the synthesis of ergot, a grain fungus that grows on rye, had psychotropic properties. After a five-year pause in this research, Hofmann again began synthesizing LSD. In 1943 he inadvertently discovered the psychotropic powers of the drug. Initially, Hofmann was unsure as to how his sensations of dizziness and visual hallucinations occurred. Upon reflecting he hypothesized that during his work a quantity of LSD had been either absorbed through the skin on his fingertips or ingested in some other way.

Hofmann was interested in the powerful and mind-altering properties of LSD and initiated a series of self-experiments under the watchful eye of his lab assistant. The greater the dosage, Hofmann discovered, the more intense the hallucinations. After this self experimentation, Hofmann notified the board of directors at the Sandoz lab and testing of LSD soon commenced under the supervision of the psychiatrist W. A. Stoll. Within five years, Sandoz Laboratories had distributed LSD in the United States and United Kingdom for use in psychotherapy. Sandoz Laboratories did not, however, engage in a formal marketing campaign for LSD. Sandoz discontinued the manufacturing of LSD in 1965 due to public and political pressure.

Therapeutic Uses

From the 1940s through the early 1960s LSD was administered in controlled environments, often in conjunction with talk therapy. The use of LSD as a part of therapy was serendipitous. LSD and other hallucinogens supported Freudian and Jungian therapeutic protocols that emphasized the role of the unconscious in the development of the healthy individual. Research from the late 1940s through the 1960s supported the notion that the effects of LSD could expedite therapy in individuals with challenging diagnoses, such as addictions, character disorders, sexual deviations, and terminal illness. With the first three problems, LSD was potentially helpful to the patient due to the principle reactions from the drug's administration: hallucinations, a feeling of well-being, spiritual transcendence, and synesthesia. These effects were used as a catalyst in assisting the patient in confronting and working through his or her repressed thoughts and experiences existing within his or her unconscious.

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