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Barbiturates are a group of drugs that depress the central nervous system (CNS) and belong to the sedative-hypnotic classification. The basic chemical derivatives used to make barbiturates come from barbituric acid. Although there are more than 20 barbituric acid derivatives, the main differences between different barbiturates are (1) their sedative or hypnotic action at a standard dose, (2) the amount of time it takes for the barbiturate to produce effects in the user, and (3) how long those effects last. Low dosages assist patents in suppressing seizures as sedatives, and as anxiolytics to reduce high anxiety. In the past, physicians typically prescribed barbiturates for high blood pressure, epilepsy, and insomnia. Most often barbiturates helped patients relax prior to surgery, and in the treatment of mental illness.

Most barbiturates come in a tablet or capsule form. However, barbiturates can also come in liquid form. Abusers sometimes crush barbiturate tablets, mixing the powder with water, thus making the substance injectable. In the hands of recreational abusers, barbiturates can have fatal consequences. There is a potential for toxic multiplying of barbiturates when they are mixed with other drugs. The combination of ingesting barbiturates with alcohol, another CNS depressant, is particularly lethal.

Barbiturates and sedatives became popular drugs of abuse in the 1960s, when they were referred to as “downers.” Barbiturates sometimes entered the drug market as diversions from legitimate companies; other sources included Mexico and other nations. However, during that era, psychedelic drug laboratories and homegrown marijuana fields eclipsed barbiturate abusers as targets of law enforcement and investigative resources. The passage of the Controlled Substance Act (CSA) and restrictions on barbiturates were intended to reduce abuse, and later a new category of anti-anxiety drugs, benzodiazepines, promoted a safer alternative to barbiturates. With the CSA making it more difficult to get barbiturates prescriptions, rates of use decreased. This is one of the few examples where making prescription access more difficult seems to have reduced use.

Terminology

Barbiturates come packaged in a variety of dosages and under different names depending on how long the barbiturate lasts. Some barbiturates are slow acting; their effects may last for as long as two days, while intermediate-acting and ultra-fast-acting barbiturate effects may last for only a few minutes. Long-lasting barbiturates, such as Phenobarbital, are rarely subject to abuse; they do not produce immediate results. The short-acting barbiturates, for example, hexobarbital, are for intravenous anesthesia. The short-term and intermediate barbiturates are the preferred drugs of abuse.

Street addicts can inject orally administered barbiturates into a muscle or vein as a substitute for their drugs of choice. Heroin addicts may turn to barbiturates as a substitute when their preferred drug is unavailable. The following generic drug names and street jargon reveal the diversity of barbiturate abuse:

  • Pentobarbital (Nembutal): Appears as a white powder on the street and is known as yellows, yellow jackets, Mexican yellows, nimbies, or nemmies. This drug serves as a hypnotic; pentobarbital is an antispasmodic for muscle tremors, but has potential for abuse.
  • Amobarbital (Amytal): Appears as a white powder marketed in blue capsules and is known on the street as blues, blue devils, blue birds, blue heaven, blue velvet, or downers. Distribution is also possible in oblong pills in yellow, orange, and green. This barbiturate is an intermediate-acting sedative to control convulsions and seizures. This drug is both fast acting and long acting, having some potential for abuse.
  • Secobarbital (Seconal): Appears as a white powder marketed in pink or red capsules and is known on the street as red devils, red birds, pinkies, pink ladies, seccies, lilly, or F-40s. This drug does not have anxiolytic qualities, but serves an effective sedative and anticonvulsant prescription.
  • Amobarbital and Secobarbital (Tuinal): Appears as a white powder marketed in blue and red capsules and is known on the street as reds and blues, rainbows, double trouble, gorilla pills, F-66s, Christmas trees, or tooies. Distribution is also possible in colorful orange, brown, and blue tablets.

Symptoms of Abuse

Barbiturates produce a sense of well-being; however, they also reduce alertness and decrease reaction time. Barbiturate symptoms include euphoria, reduced anxiety, the relaxing of inhibitions, poor coordination, and dizziness. Barbiturate abusers often engage in high-risk behaviors, such as driving under the influence of the drug. The drug mimics the symptoms of alcohol such as euphoric highs, sleepiness, and passing out. Dosage increases can cause more sleepiness, and considerable stupor. Overdose may lead to depressed respiratory function, coma, and death. Because barbiturate overdose can lead to death, barbiturates are used as a suicide agent.

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