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It is generally believed that aggressive and violent behavior arises from the combination of hereditary influences and the effects of several environmental risk factors. However, some early researchers argued that criminal and violent behavior was mainly explained by hereditary factors. For instance, Cesare Lombroso, an Italian doctor, theorized that “born criminals” could be distinguished by atavistic stigmata (physical features) such as a large jaw, sloping forehead, or a single palmar crease. Later, in the 1960s, the relationship between heredity factors and criminality was highlighted by the so-called XYY syndrome. This came about because several studies had suggested that affected individuals commit criminal and violent acts more frequently than expected. Given that normal XY males display higher levels of violence and aggression than females, one plausible hypothesis is that having an extra Y chromosome might contribute to even higher levels of crime and violence in XYY males.

The XYY Syndrome or 47,XYY Males

XYY syndrome is a chromosome disorder that only affects males. Males with this disorder have a duplicate Y chromosome. A chromosome is a structure of DNA and protein that is found in the cell nucleus. Humans have 23 pairs of chromosomes, a total of 46. In each set of chromosomes, 2 are known as the sex chromosomes (X and Y), and the other 22 pairs are referred to as the autosomes. Human females have two X chromosomes, whereas males have one X and one Y chromosome. Each parent contributes one chromosome to each pair; so a child gets half of his or her chromosomes from the mother and the other half from the father. Within each chromosome, there are numerous genes and each gene occupies a specific position on a chromosome. Genes control physical traits such as eye color, hair texture, and height. Genes also influence the predisposition to temperaments and traits, or liability toward a disease or mental disorder. For example, specific genes may account for a predisposition to schizophrenia. In some rare instances, a chromosome anomaly occurs in males. Instead of one Y chromosome being transmitted from the father, two copies of the Y chromosome are transmitted, pairing with one X. Rather than having 46 chromosomes, therefore, a male receives an extra Y chromosome, producing what is called a 47,XYY karyotype. Karyotype is a summary of the chromosome constitution of a person. The 47,XYY karyotype does not result from any genetic factor but instead occurs randomly during meiosis in a single generation. Meiosis is the process whereby sperm or egg cells are produced. Since the 47,XYY karyotype is the result of a random error during meiosis, it does not run in families and therefore is not considered to be heritable.

Sex chromosome anomalies such as XYY are less likely to be spontaneously aborted, compared with chromosome anomalies related to the autosomes. Sex chromosome anomalies also seem to produce less severe clinical manifestations than autosome anomalies.

Epidemiology

The incidence of 47,XYY karyotype is 1 per 1,000 males. In other words, one boy in about 1,000 boys are born with a 47,XYY karyotype. The majority of XYY males go through life without knowing their karyotype. It is estimated that around 10 percent of these males are detected prenatally when the mother undergoes examination to detect other chromosomal anomalies such as Down's syndrome. The usual indications for those being karyotyped postnatally are developmental delay in motor and cognitive milestones and/or behavior problems during childhood.

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