With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field. The 31 chapters are divided into four parts: Part I Determination of Substance Misuse Part II PK and PD in Relation to Patterns of Use Part III Detection and Treatment of Drug and Alcohol Use Part IV Controversies and New Approaches This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.

Chapter 3: Future Directions: The Role of Pharmacogenomics

Future Directions: The Role of Pharmacogenomics

Future Directions: the Role of Pharmacogenomics
Jason M WhiteAndrew A Somogyi

It is inevitable that genetic information will become both increasingly available and of increasing importance in the health system. As a consequence of these developments, genetic information that is relevant to drug use and addiction will also become available. That information has the potential to transform our understanding of drug use and drug-related problems, both at a general level and at the level of the individual user and treatments.

How can genotype influence the effects of a drug?

Genotype can influence the concentration of the drug reaching its site of action and the activity of the drug. Concentration at the site is determined by the action of enzymes impacting on drug ...

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