With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field. The 31 chapters are divided into four parts: Part I Determination of Substance Misuse Part II PK and PD in Relation to Patterns of Use Part III Detection and Treatment of Drug and Alcohol Use Part IV Controversies and New Approaches This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.
Chapter 2: Basic Pharmacokinetics of Substance Misuse
Basic Pharmacokinetics of Substance Misuse
Pharmacokinetics has been variously been defined as the study of the relationship between administered doses of a drug and the observed blood (plasma or serum) or tissue concentrations. It is a branch of pharmacology that explores what the body does to a drug and hence concerns itself with the quantitation of drug absorption, distribution, metabolism and excretion (ADME), and more recently liberation (LADME).
Despite the huge size of the pharmaceutical industry and the vast array of psychoactive substances available today for use, the mode of action of drugs in the body can be understood by reference to basic pharmacokinetic principles, assuming a linear relationship between blood and tissue (brain) exposure. Understanding the pharmacokinetic principles of ...