With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field. The 31 chapters are divided into four parts: Part I Determination of Substance Misuse Part II PK and PD in Relation to Patterns of Use Part III Detection and Treatment of Drug and Alcohol Use Part IV Controversies and New Approaches This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.

Chapter 1: Genetics and Genomics in Addiction Research

Genetics and Genomics in Addiction Research

Genetics and Genomics in Addiction Research
Rohit Jaibhagwan LodhiDavid RossolatosKatherine Jean Aitchison

Introduction

Substance use disorders are complex, multifactorial disorders that are typically characterized by the repeated use of a psychoactive substance that continues despite harmful consequences or varying degrees of impairment in function (American Psychiatric Association, 2013). Internet addiction, gambling disorders and sexual addiction are examples of a broader concept of addictions that is not simply limited to psychoactive substance use. The current approach towards studying genetic influences in such addictions involves much more than looking at the dichotomy of a disorder being present or absent. Agrawal et al. (2012) highlighted the importance of looking at addiction in stages, with early stages being less affected by genetic factors than the ...

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