With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field. The 31 chapters are divided into four parts: Part I Determination of Substance Misuse Part II PK and PD in Relation to Patterns of Use Part III Detection and Treatment of Drug and Alcohol Use Part IV Controversies and New Approaches This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.

Chapter 18: Biomarkers of Alcohol Misuse

Biomarkers of Alcohol Misuse

Biomarkers of Alcohol Misuse
Natalie E WalshamRoy A Sherwood


Alcohol misuse has a wide distribution among all socioeconomic and ethnic groups worldwide with an estimated global lifetime prevalence of 16% in the adult population. Alcoholism is associated with significant morbidity and mortality. In its most recent report on alcohol, the World Health Organization (WHO 2011) estimated that more than 70 million people worldwide could be considered to have an alcohol use disorder (AUD) based on the classification in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and that AUD was responsible for 2.25 million or 3.8% of the total number of deaths in the world each year. In the UK, the Health and Social Care Information Centre estimated that AUDs cost ...

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