With contributions from leading international academics across the biological sciences, this handbook takes a critical look at the key contemporary issues and debates in the field. The 31 chapters are divided into four parts: Part I Determination of Substance Misuse Part II PK and PD in Relation to Patterns of Use Part III Detection and Treatment of Drug and Alcohol Use Part IV Controversies and New Approaches This Handbook is an excellent reference text for the growing number of academics, students, scientists and practitioners in the drug and alcohol studies community, and will be a vital resource to the allied professions involved in work-place drug testing, clinical toxicology, and forensic science.

Chapter 6: Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs

Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs

Opioids: A Discussion of Pharmacokinetics and Pharmacodynamics in Those Who Misuse Drugs
Verena E. MetzSandra D. Comer

Broadly speaking, people abuse opioid drugs for the pleasant effects they induce, such as euphoria, feelings of warmth and safety and pain relief. However, many variables contribute to the magnitude of the effects that are produced by each compound, including pharmacological characteristics of the drugs themselves, characteristics of the individuals using the drugs, and the external conditions under which the drugs are taken.

This chapter summarizes pharmacological and individual characteristics that may play an important role in the misuse/abuse of opioids in humans.

PHARMACOLOGICAL CHARACTERISTICS

Potency and efficacy

Two important concepts to consider when discussing the pharmacology of drugs are potency ...

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