Summary
Contents
Subject index
The `effectiveness revolution' both in research and clinical practice, has tested available methods for health services research to the extreme. How far can observational methods, routine data and qualitative methods be used in health care evaluation? What cost and outcome measures are appropriate, and how should data be gathered? With the support of over two million pounds from the British Health Technology Assessment Research Programme, the research project for this Handbook has led to both a synthesis of all of the existing knowledge in these areas and an agenda for future debate and research. The chapters and their authors have been selected through a careful process of peer review and provide a coher
Meta-Analysis in Health Technology Assessment
Meta-Analysis in Health Technology Assessment
Summary
Use of systematic review and meta-analytic methods in health technology assessment (HTA) and related areas is now common. This chapter focuses on the quantitative pooling, or meta-analytical aspects of the systematic review process. Methods for combining binary, continuous and ordinal outcome data are discussed. Fixed effects, random effects and Bayesian modelling have all been advocated for meta-analysis. All are described, and the results from their corresponding analyses compared. Next, methods to include covariates, which could potentially explain between-study heterogeneity, are outlined. A practical example using binary outcomes is presented for all these methods. Brief consideration is given to new and other developments. These include methods for the review of disparate sources of ...
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