Reflecting the enormous changes that have taken place in our knowledge and understanding of developmental disorders, this groundbreaking international volume brings this vast and complex field together for the first time. The editors have collected together the world’s leading academic scholars and clinicians, to explore how current research across a range of different disciplines can inform academic knowledge and clinical practice and help to improve the lives of individuals and their families.The SAGE Handbook of Developmental Disorders is a central reference in the field for all academics, researchers, clinicians and advanced students involved in the study of developmental disorders, including those in clinical psychology, child psychiatry, child mental health, child genetics and pediatrics, speech language pathology, and developmental disabilities and special education.
Our aim in this chapter is to describe the clinical features of the Rett disorder (RD), to indicate the associated genetic, anatomical and physiological disturbances that underlie its problems and to discuss some interventions that have been found effective and recent initiatives that may lead to more radical treatment. Figure 8.1 shows one person with RD as a child and as an adult.
This predominantly female, profoundly disabling developmental neurological disorder results from mutations in the X-linked gene for the methyl CpG binding protein (MECP2) (Amir et al., 1999) and is called after Andreas Rett, the Austrian neurologist who described it (Rett, 1966). The prevalence has been estimated at 1 in 10,000 females under 14 years (Hagberg, 1993; Hagberg & Hagberg, 1997; Kerr, ...