- Subject index
Reflecting the enormous changes that have taken place in our knowledge and understanding of developmental disorders, this groundbreaking international volume brings this vast and complex field together for the first time. The editors have collected together the world’s leading academic scholars and clinicians, to explore how current research across a range of different disciplines can inform academic knowledge and clinical practice and help to improve the lives of individuals and their families.The SAGE Handbook of Developmental Disorders is a central reference in the field for all academics, researchers, clinicians and advanced students involved in the study of developmental disorders, including those in clinical psychology, child psychiatry, child mental health, child genetics and pediatrics, speech language pathology, and developmental disabilities and special education.
Chapter 5: Williams Syndrome: Overview and Recent Advances in Research
Williams Syndrome: Overview and Recent Advances in Research
Williams syndrome (WS) was first discovered in the early 1960s by Williams et al. (1961) and Beuren et al. (1962), who independently described patients with cardiac problems, hypercalcemia, developmental delay, and unusual but striking facial characteristics. Children with some of these symptoms had previously been referred to as having ‘idiopathic hypercalcemia of infancy’ (Bongiovanni et al., 1957) but the link to cardiac abnormalities had not been recognized. Although it was initially thought to be an extremely rare condition, current estimates range from 1 in 7500 (Stromme et al., 2002) to 1 in 20,000 (Morris et al., 1988). It is now known that WS is caused by ...