The Honolulu Heart Program (HHP) is a prospective cohort of 8,006 Japanese American men living in Oahu, Hawaii, born between 1900 and 1919 (45 to 68 years old at the time of enrollment). The main objective of the HHP was to identify risk factors for cardiovascular and cerebrovascular disease. The HHP started in 1965 and was funded by the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health. The HHP is part of a larger study called the NI-HON-SAN study, which stands for Nippon, Honolulu, and San Francisco. The NI-HONSAN study included men of Japanese ancestry born in the same period as the HHP who were living in Japan and San Francisco.

By observing Japanese Americans who had immigrated to Hawaii, the ...

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