In this chapter, we briefly summarize pharmacotherapy for depression. We discuss reviews of the treatment outcome literature and randomized controlled trials. Then the major types of antidepressant medication are covered. We use a blend of classification schemes for antidepressant medications, taken from several reviews by experts (e.g., American Psychiatric Association, 2000b; Nemeroff & Schatzberg, 1998; Thase & Kupfer, 1996). The major types of Food and Drug Administration (FDA)-approved antidepressant medications are the following: (a) tricyclics, (b) selective serotonin reuptake inhibitors (SSRIs), (c) monoamine oxidase inhibitors (MAOIs), and (d) second-generation and other agents: tetracyclics, dopamine-norepinephrine reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, serotonin modulators, and norepinephrine-serotonin modulators. We summarize research on combined approaches to treatment where pharmacotherapy and psychotherapy are used together. Then we provide clinical guidelines ...