• Summary
  • Contents
  • Subject index

Every health care provider and mental health professional will encounter clients struggling with depression, yet many of these professionals don’t receive a thorough grounding on theory, research, and clinical guidelines regarding depression, and those who do sometimes have trouble keeping abreast of the literature (a literature that includes over 60,000 empirical publications since 1980!). This book provides a handy reference for such practitioners. This brief, practical guide provides an introduction or refresher on depression that is research-based yet accessible, practical, and easy to read and consult. 


In this chapter, we briefly summarize pharmacotherapy for depression. We discuss reviews of the treatment outcome literature and randomized controlled trials. Then the major types of antidepressant medication are covered. We use a blend of classification schemes for antidepressant medications, taken from several reviews by experts (e.g., American Psychiatric Association, 2000b; Nemeroff & Schatzberg, 1998; Thase & Kupfer, 1996). The major types of Food and Drug Administration (FDA)-approved antidepressant medications are the following: (a) tricyclics, (b) selective serotonin reuptake inhibitors (SSRIs), (c) monoamine oxidase inhibitors (MAOIs), and (d) second-generation and other agents: tetracyclics, dopamine-norepinephrine reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, serotonin modulators, and norepinephrine-serotonin modulators. We summarize research on combined approaches to treatment where pharmacotherapy and psychotherapy are used together. Then we provide clinical guidelines ...

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