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“The presentation is consistently excellent. One, the writing is lucid and organized in a way that should be very natural for the clinical reader. Two, the text requires no background in mathematics and uses a minimum of symbols. And, three, the methodological concepts and clinical issues are well integrated through a number of carefully prepared and comprehensive examples.” — Greg Samsa, Associate Director, Duke Center for Clinical Health Policy Research. If a patient is older or younger than, sicker or healthier than, taller or shorter than or simply different from the subjects of a study, do the results pertain? Clinical Epidemiology & Evidence-based Medicine is a resource for all health-care workers involved in applying evidence to the care of their patients. Using clinical examples and ...


Consider a 48-year-old woman presenting to the office with a complaint of chest pain. The immediate concern is angina pectoris. Why? Because the condition is both common and dangerous. Our minds are immediately triggered by considerations of probability and risk.

The history is conducted as a sequence of hypothesis tests. The answer to each ...

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