Drug-facilitated sexual assault (DFSA) refers to offenses in which victims are subjected to noncon-sensual sexual acts while unconscious or incapacitated because of the effects of drugs or alcohol. DFSA is an especially troubling crime in that victims often have no memory of the sexual assault. Victims may experience a wide range of trauma symptoms and therefore clinicians, researchers, law enforcement personnel, and policymakers need to be well informed about the nature and impact of this crime. This entry explores the conceptualization of DFSA, prevalence estimates, substances commonly used, contexts and perpetrators, effects on victims, and treatment and prevention.