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Wound healing is a complex process by which tissue repairs itself after injury, involving the interaction of stem cells, differentiated cells, cytokine factors, and extracellular matrix. Physiologically, this process occurs via sequential activation of local and systemic cells to restore tissue integrity via regeneration and scar formation. Pathologic wound healing occurs when this process is interrupted and can result in nonhealing wounds or excessive scarring. Because stem cells play a key part in wound healing, understanding their physiology may contribute to therapeutic applications.

Phasic Model of Wound Healing

Wound healing requires intricate coordination of many cell types, normally occurring in three overlapping phases: inflammation, proliferation, and remodeling. Before the first phase can commence, coagulation and hemostasis must occur, forming a clot to prevent further blood loss. In ...

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