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Stem cells, including those derived from embryonic tissues, as well as those induced into pluripotency, serve as an essential source for precursor cells for the study of hematopoiesis. These pluripotent cell populations have been extensively used in the development of cell-based treatments for various hematological disorders and cancers. Hematopoietic precursor cells derived from human embryonic stem cells (ESCs) have been recently shown to be capable of producing natural (NK) cells, thus emphasizing the importance of this universal source for antitumor lymphocytes for innovative clinical treatments.

Human ESCs and Hematopoietic Precursor Cells

Almost 20 years ago, landmark studies described the potential use of human ESCs in investigating processes involved in hematopoiesis. Since then, several studies have focused on the mechanisms and cofactors associated with the generation of various ...

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