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Stem cells are implicated in the development of many skin pathologies, and evolving research is changing researchers’ understanding of carcinogenesis. Stem cells are also potential targets for the treatment of various skin pathologies, and an understanding of their role in these diseases may help pave the way for novel therapies.

Cancer Stem Cells

Malignant tumors, according to the cancer stem cell hypothesis, are composed of cancer stem cells and differentiated cancer cells. Sharing properties with normal adult stem cells, cancer stem cells (CSCs), which are rare within a tumor, can self-renew and divide to form daughter cells. These daughter cells can then differentiate into any cell type found within the tumor. Since CSCs express multidrug resistant genes, they are very resistant to chemotherapy and targeted molecular ...

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