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Skin: Existing or Potential Regenerative Medicine Strategies

The skin is the body’s first line of defense against pathogens and against radiation damage and water loss, as well as being critical for preserving the health of the organism. Understanding the mechanism of wound healing is important for developing strategies for skin regeneration and for preventing the development of chronic wounds.

Skin Wound Healing

There are three phases of wound healing: inflammation, proliferation, and remodeling. The inflammatory phase recruits cells to clean up the wound site via clotting, vasoconstriction, vasodilation, neutrophils, and macrophagic action. The proliferative phase creates new blood vessels to increase blood flow to the wound while fibroblasts accumulate in the wound. These fibroblasts excrete collagen to help close the wound. When collagen production and degradation equalize, the remodeling, or maturation phase, of ...

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