Mouse Models to Study Stem Cells

In the field of biomedical research, various organisms have been used as models of specific biological processes to attain a better understanding of developmental, genetic, pathological, physiological, and toxicological processes. Historically, the mouse has been the most commonly used species for studying human diseases; the same holds true in the advent of cell-based therapies. Mice are used in the generation of pluripotent stem cells, as well as somatic cells, which can be induced to undergo reprogramming.

The Mouse as a Disease Model

For several decades, scientists have engaged in research involving various animals to establish mechanisms associated with specific biological activities. These model organisms serve as exemplary representations of human conditions, especially when a specific biological phenomenon shows similarities between the model organism and humans. For example, ...

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