The mouse is a powerful and indispensable tool for the study of human health and diseases. Mouse models have contributed enormously to the study of embryonic stem cells (ESCs). Since ESCs were first isolated, various stem cell technologies, such as gene targeting and induced pluripotent stem cell (iPSC) technology have been developed. ESC research opened a new chapter of developmental biology and genetics.

History of Mouse Embryonic Stem Cell Research

The mouse has been widely used in laboratory research for centuries, and the research using the mouse model has formed the basis of biomedical science. Most achievements of early ESC research were done with mouse models as the research tool. The history of mouse ESC research began in 1953 with embryologist Leroy Stevens. While performing cancer research ...

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