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Mesenchymal: Development and Regeneration Potential

Mesenchymal stem cells have the potential to differentiate into various cell lineages. In the pioneer study by A. J. Friedenstein and colleagues in the 1970s, mesenchymal stem cells were induced to differentiate into fibroblast cells, adipocytes, osteocytes, and chondrocytes in vitro. The ability to differentiate into fibroblast cells, adipocytes, osteocytes, and chondrocytes in vitro is one of the three criteria defining mesenchymal stem cells.

Mesenchymal Stem Cell-Derived Cells

Adipocytes. Adipocytes are mainly involved in metabolism and storage of fat, and they are the major cell type in adipose tissue. Adipocytes are derived from mesenchymal stem cells, which reside in the vascular stroma in adipose tissue. Adipogenesis is triggered by signals of high energy intake and glucose uptake. Mesenchymal stem cells are committed to preadipocytes under the ...

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