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Clinical Trials Outside the United States: Stroke

Stroke is a leading cause of death and disability worldwide. It is the second-highest cause of death worldwide (after ischemic heart disease), with over 5 million deaths per year globally. It has two subtypes, hemorrhagic and ischemic, and the latter makes up the majority of all strokes—almost 80 percent of the total. Following stroke, many patients develop long-term disability and there is a realistic need to devise treatment strategies for reducing debilitation. Cell-based therapies have the potential to open up new avenues of treatment in this arena. Targets for stem cell therapy include neuroprotective approaches aimed at protecting at-risk tissue as well as neuro-reparative approaches, which may involve direct replacement of damaged brain tissue. In stroke, the damage process is acute; also, multiple cell ...

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