Clinical Trials, U.S.: Crohn’s Disease

Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract with many extra intestinal manifestations as well. It can affect any part of the digestive tract, from oral cavity to anal canal. The most common site of involvement is the small bowel, and in particular, the ileum. It usually presents with abdominal pain, diarrhea (at times bloody), weight loss, and fever. Extraintestinal manifestations include joint and skin problems.

Presented in a paper by Burrill Bernard Crohn and colleagues for the first time in 1932, the etiology of disease is not clear to date. In the United States, around 1.4 million people suffer from the disease. Many treatment regimens are emerging in an effort to find a cure to decrease the disease burden and reduce its ...