Adipose: Major Pathologies

Adipose tissue consists of adipocytes, a dynamic and highly regulated population of cells, and a stromal vascular fraction, which includes preadipocytes. Adipogenesis results in the generation of adipocytes from preadipocytes, which arise from a multipotent stem cell of mesodermal origin. This article focuses on stem cells as they relate to adipogenesis and how the dysfunction of adipogenesis is responsible for the role of adipose cells in the development of pathology.


Patients with lipodystrophy have a variable lack of adipose tissue, with the severity of the pathology being determined by the magnitude of fat absence. Lipodystrophies are categorized as genetic or inherited. Genetic lipodystrophies are monogenetic disorders caused by mutations in a gene. Inherited lipodystrophies have several identified genes as a cause, with congenital generalized lipodystrophy ...

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