The most daunting, and among the most important, of all clinical responsibilities, suicide assessment requires therapists to determine to the best of their ability whether the client in front of them is in imminent danger of making an attempt on his or her life. This entry introduces the most salient topics to address during a suicide assessment, and it offers suggestions for how best to conduct an interview devoted to determining suicidality. Assessment is inexorably linked to preventive action when clinicians conclude that the risk of death is high, so this entry also includes guidelines for making a safety decision regarding hospitalization and, when hospitalization isn’t necessary, for collaborating with clients on the construction of an idiosyncratic safety plan.