Sexuality within the context of aging can be defined broadly as sexual activity (e.g., kissing; petting; anal, oral, and vaginal intercourse; masturbation), sensual activity (e.g., holding hands, hugging, dancing, wearing body lotion), and emotional intimacy experienced by middle-aged (aged 50–64) and older adults (aged 65 and older). Although research suggests that many adults engage in sexual activity well into their 80s, aging LGBTQ adults often face significant challenges to the expression of their sexuality. This entry will discuss what is known about the sexuality of middle-aged and older LGBTQ adults, and how it is influenced by ecological factors such as age cohort, stigma, discrimination, sexual dysfunction, health disparities, socioeconomic status, ethnicity, and institutional factors.