Herpes Simplex

Herpes simplex (HS) is a viral disease caused by infection with the herpes simplex virus (HSV), either type 1 or type 2 (HSV-1, HSV-2). HS can affect neonates, children, and adults and can cause a wide spectrum of diseases. The disease is commonly classified into three types: type 1, which is localized to the skin, eyes, and mouth and is termed SEM disease; type 2, which is localized to the central nervous system (CNS); and type 3, which is a disseminated disease involving multiple organs, including the CNS. A particularly severe manifestation of HSV infection is the development of herpes simplex encephalitis (HSE). This condition is characterized by infection and inflammation of the brain parenchyma and is associated with high mortality and morbidity rates. In ...