Agenesis of the Corpus Callosum

The corpus callosum is the largest fiber tract in the brain and provides the primary means of communication between the two hemispheres. Agenesis of the corpus callosum (AgCC), also called callosal agenesis, occurs when this structure fails to develop during the prenatal period. Agenesis may be partial (an individual section fails to develop) or complete (the entire corpus callosum fails to form). Hypoplasia is a related condition in which the corpus callosum forms along its anteroposterior axis but fibers are underdeveloped.

AgCC is seen in a number of neurodevelopmental conditions and genetic syndromes, likely in part reflecting multiple genetic and environmental causes. AgCC is associated with a pattern of cognitive strengths and weaknesses that most often impacts social and emotional functioning, often to a degree that ...

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