Developmental disabilities (DD) are a group of conditions resulting in physical, intellectual, and behavioral impairments. These conditions occur during early development, are usually attained by the age of 22 years old, and continue throughout a person’s lifetime. Nutrition plays a vital role in children with DD, specifically those with cerebral palsy (CP), spina bifida, autism spectrum disorders (ASD), Down syndrome (DS), Rett syndrome, Prader–Willi syndrome (PWS), and seizure disorders. This entry reviews growth, diet, and feeding problems and explores nutritional therapies for individuals with DD.