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Mosaicism
Mosaicism is a biological phenomenon that describes the presence of two or more populations of cells within an individual. The genetic differences that distinguish these populations of cells are thought to arise from postzygotic events, such as mutations or abnormal cellular division. Mosaicism has been implicated in over 30 disorders that show variable expressivity, including mitochondrial disorders, cancer, and developmental disorders. This entry describes the history of mosaicism; its proposed causes, detection, and clinical manifestations; and the use of genetic mosaics in experimental biology.
The Origins of Mosaicism
The term mosaisicm was first used by U.S. geneticist Curt Stern in the 1930s to describe his observation of unusual genetic recombination during somatic cell division. Mosaicism is derived from the word mosaic, which refers to the artistic arrangement ...
- Assessment and Diagnosis
- Diagnostic and Statistical Manual of Mental Disorders
- International Classification of Diseases, 10th Revision
- International Classification of Diseases, History of
- Academic Achievement Tests
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- Flynn Effect
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- Conservatorship
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- Decision-Making Capacity
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- Free Appropriate Public Education
- Funding Services for Adults With Developmental Disabilities and Autism Spectrum Disorder
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- Acquired Pediatric Brain Damage
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- Autism Spectrum Disorder, Biology of
- Basal Ganglia
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- Brainstem
- Central Nervous System
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- Cognitive Neuroscience of Intelligence
- Concussion
- Corpus Callosum
- Cross Disorder Genetic Risk
- Developmental Psychopathology
- Down Syndrome: Medical Concerns and Comorbid Disorders
- Encephalitis
- Endophenotypes
- Failure to Thrive
- Frontal Lobes
- Genetics of Intellectual Development
- Hemispheric Asymmetries
- Herpes Simplex
- Hormones
- Human Genome Project
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- Iatrogenic Effects
- Intellectual Disability, Biology of
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- Limbic System
- Maternal Substance Abuse
- Media Use by Individuals With Intellectual and Developmental Disabilities
- Meningitis
- Microcephaly
- Monogenic Disorders
- Mosaicism
- Myelination and Connectivity
- Neural Plasticity
- Neuroimaging Methods
- Neurotransmitters
- Nutrition in Childhood and Adolescence
- Nutrition, Prenatal
- Nutrition: Importance in First Years of Life
- Polygenic Risk
- Postnatal Risk Factors
- Prenatal Risk Factors
- Preterm Birth
- Rubella
- Temporal Lobe
- Teratogens
- Theories and Causes: Psychological and Sociocultural Perspectives
- Attachment Theory
- Autism, Rising Prevalence of: Epidemiology
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- Disability Discrimination: U.S. Supreme Court Cases
- Down Syndrome: Cognitive, Emotional, and Behavioral Presentation
- Ecological Systems Theory
- Environmental Considerations in Social Participation of Children With Developmental Disabilities
- Environmental Risk Factors
- Erikson’s Theory of Psychosocial Development
- Gardner’s Theory of Multiple Intelligences
- Intelligence, Theories of
- Intelligence: Environmental Factors
- Piaget’s Theory of Cognitive Development
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- Accessible Design
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- Augmentative and Alternative Communication
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- Classroom Aides
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- Dementia
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- Discrete Trial Training
- Early Intervention
- Early Start Denver Model
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- Extinction
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- Flooding
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- Functional Inclusion
- Intellectual Disability: Historical Changes in Terminology
- Male Brain Theory of Autism
- Mentoring
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- Personalized Supports
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- Physical Therapy
- Picture Exchange Communication System
- Pivotal Response Therapy
- Portage Project
- Positive Parenting of Children With Intellectual and Developmental Disabilities
- Prenatal Care
- Probiotics
- Psychopharmacological Interventions
- Relationship Development Intervention
- Social Inclusion
- Speech and Language Pathologists
- Stimulant Medications
- Systematic Desensitization
- Technology for Individuals With Intellectual and Developmental Disabilities
- Treatment Planning
- UCLA Young Autism Project
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